4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzenamine

Base Information

• Chemical Name: 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzenamine
• CAS No.: 1239963-48-4
• Molecular Formula: C₂₆H₂₃ClF₃N₃OS
• Molecular Weight: 518.002

Synonyms:4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzenamine

Chemical Property of 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzenamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzenamine

There total 19 articles about 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylcarbamate (1239963-47-3) → 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzenamine (1239963-48-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

2-(4-chloro-3-methoxyphenyl)-2-methylpropanoic acid (1239963-78-0) → 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzenamine (1239963-48-4)

Guidance literature:

Multi-step reaction with 11 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

2: tetrahydrofuran / 2 h / -78 - 20 °C

3: tetra-n-butylammonium tribromide / dichloromethane; methanol / 3 h / 0 - 20 °C

4: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

5: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 5 h / 3361.55 Torr

6: triethylamine / dichloromethane / 1 h / 0 - 20 °C

7: acetic acid / 4 h / Reflux

8: caesium carbonate / acetonitrile / 2 h

9: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

10: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 0 - 80 °C

11: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With hydrogenchloride; dmap; sodium azide; tetra-n-butylammonium tribromide; diphenyl phosphoryl azide; hydrogen; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

2-(4-chloro-3-methoxyphenyl)-N-methoxy-N,2-dimethylpropanamide (1239963-79-1) → 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzenamine (1239963-48-4)

Guidance literature:

Multi-step reaction with 10 steps

1: tetrahydrofuran / 2 h / -78 - 20 °C

2: tetra-n-butylammonium tribromide / dichloromethane; methanol / 3 h / 0 - 20 °C

3: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

4: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 5 h / 3361.55 Torr

5: triethylamine / dichloromethane / 1 h / 0 - 20 °C

6: acetic acid / 4 h / Reflux

7: caesium carbonate / acetonitrile / 2 h

8: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

9: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 0 - 80 °C

10: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With hydrogenchloride; sodium azide; tetra-n-butylammonium tribromide; diphenyl phosphoryl azide; hydrogen; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

upstream raw materials:

tert-butyl 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylcarbamate

3,5-difluorobenzoic acid

5-Bromo-2-chloroanisole

5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

Downstream raw materials:

C₂₆H₂₁Cl₂F₃N₂O₃S₂

4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzenesulfonic acid

(R)-methyl 2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

(R)-3-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluoro-N-(1-methoxy-1-oxopropan-2-yl)phenylsulfonamido)-N,N,N-trimethylpropan-1-aminium 2,2,2-trifluoroacetate

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