(R)-methyl 2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

Base Information

Chemical Name:(R)-methyl 2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate
CAS No.:1239957-04-0
Molecular Formula:C₃₀H₂₉ClF₃N₃O₅S₂
Molecular Weight:668.158
Hs Code.:

(R)-methyl 2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

Synonyms:(R)-methyl 2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

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Chemical Property of (R)-methyl 2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

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Technology Process of (R)-methyl 2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

There total 22 articles about (R)-methyl 2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 7625-53-8,10065-72-2,21705-13-5
D-alanine methyl ester

: 1239957-03-9
4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzenesulfonic acid

: 1239957-04-0
(R)-methyl 2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

Guidance literature:: 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzenesulfonic acid; With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 1.5h; Reflux;

D-alanine methyl ester; With sodium carbonate; In acetonitrile; at 0 ℃; for 0.75h; Product distribution / selectivity;

Reference yield:

: 1239963-47-3
tert-butyl 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylcarbamate

: 1239957-04-0
(R)-methyl 2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

2.1: hydrogenchloride; sodium nitrite; acetic acid / water / 4 - 6 °C

2.2: 1.33 h / 5 °C

3.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 1.5 h / Reflux

3.2: 0.75 h / 0 °C

With hydrogenchloride; thionyl chloride; acetic acid; N,N-dimethyl-formamide; trifluoroacetic acid; sodium nitrite; In dichloromethane; water;

Reference yield:

: 1239963-48-4
4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzenamine

: 1239957-04-0
(R)-methyl 2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite; acetic acid / water / 4 - 6 °C

1.2: 1.33 h / 5 °C

2.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 1.5 h / Reflux

2.2: 0.75 h / 0 °C

With hydrogenchloride; thionyl chloride; acetic acid; N,N-dimethyl-formamide; sodium nitrite; In dichloromethane; water;