2-[3-(1-benzyl-piperidin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide

Base Information

Chemical Name:2-[3-(1-benzyl-piperidin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide
CAS No.:220392-03-0
Molecular Formula:C₂₃H₂₉N₃O₂S
Molecular Weight:411.568
Hs Code.:

Synonyms:2-[3-(1-benzyl-piperidin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide

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Chemical Property of 2-[3-(1-benzyl-piperidin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide

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Technology Process of 2-[3-(1-benzyl-piperidin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide

There total 3 articles about 2-[3-(1-benzyl-piperidin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1-benzyl-1-methyl-4-[5-(2-methylsulfamoyl-ethyl)-1H-indol-3-yl]-piperidinium bromide

: 121679-13-8
naratriptan

: 220392-03-0
2-[3-(1-benzyl-piperidin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide

Guidance literature:: With lithium triamylborohydride; In tetrahydrofuran; for 26h; Heating;
DOI:10.1002/(SICI)1099-1344(199812)41:12<1127::AID-JLCR158>3.0.CO;2-9

Reference yield:

: 100-39-0
benzyl bromide

: 220392-03-0
2-[3-(1-benzyl-piperidin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / acetone

2: 44 percent / lithium trisamylborohydride / tetrahydrofuran / 26 h / Heating

With lithium triamylborohydride; In tetrahydrofuran; acetone; 1: quaternisation / 2: dequaternisation;
DOI:10.1002/(SICI)1099-1344(199812)41:12<1127::AID-JLCR158>3.0.CO;2-9

Reference yield:

: 121679-13-8
naratriptan

: 220392-03-0
2-[3-(1-benzyl-piperidin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / acetone

2: 44 percent / lithium trisamylborohydride / tetrahydrofuran / 26 h / Heating

With lithium triamylborohydride; In tetrahydrofuran; acetone; 1: quaternisation / 2: dequaternisation;
DOI:10.1002/(SICI)1099-1344(199812)41:12<1127::AID-JLCR158>3.0.CO;2-9