2-(2-fluoroethoxy)-5-methyl-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)-trans-butyl-2-enyl)benzamide

Base Information

• Chemical Name: 2-(2-fluoroethoxy)-5-methyl-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)-trans-butyl-2-enyl)benzamide
• CAS No.: 1269797-36-5
• Molecular Formula: C₂₅H₃₂FN₃O₃
• Molecular Weight: 441.546
• Mol file: 1269797-36-5.mol

Synonyms:2-(2-fluoroethoxy)-5-methyl-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)-trans-butyl-2-enyl)benzamide

Chemical Property of 2-(2-fluoroethoxy)-5-methyl-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)-trans-butyl-2-enyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-fluoroethoxy)-5-methyl-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)-trans-butyl-2-enyl)benzamide

There total 5 articles about 2-(2-fluoroethoxy)-5-methyl-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)-trans-butyl-2-enyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-(4-(2-methoxyphenyl)piperazin-1-yl)-trans-but-2-en-1-amine (144009-85-8) + 2-(2-fluoroethoxy)-5-methylbenzoic acid (1269797-08-1) → 2-(2-fluoroethoxy)-5-methyl-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)-trans-butyl-2-enyl)benzamide (1269797-36-5)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm101323b

Reference yield:

Methyl 2-(2-fluoroethoxy)-5-methylbenzoate (1315561-84-2) → 2-(2-fluoroethoxy)-5-methyl-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)-trans-butyl-2-enyl)benzamide (1269797-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1: water; sodium hydroxide / methanol / 20 °C

2: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

With water; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium hydroxide; In methanol; dichloromethane;

DOI:10.1021/jm101323b

Reference yield:

5-Methylsalicylic acid (89-56-5) → 2-(2-fluoroethoxy)-5-methyl-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)-trans-butyl-2-enyl)benzamide (1269797-36-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid / Reflux

2: potassium carbonate / acetone / Reflux

3: water; sodium hydroxide / methanol / 20 °C

4: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

With sulfuric acid; water; potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium hydroxide; In methanol; dichloromethane; acetone; 1: Fischer esterification;

DOI:10.1021/jm101323b

upstream raw materials:

4-(4-(2-methoxyphenyl)piperazin-1-yl)-trans-but-2-en-1-amine

2-(2-fluoroethoxy)-5-methylbenzoic acid

Methyl 2-(2-fluoroethoxy)-5-methylbenzoate

5-Methylsalicylic acid