4-amino-quinazoline-8-carboxylic acid [6-fluoro-2-methoxy-3-(propane-1-sulfonylamino)-phenyl]-amide

Base Information

Chemical Name:4-amino-quinazoline-8-carboxylic acid [6-fluoro-2-methoxy-3-(propane-1-sulfonylamino)-phenyl]-amide
CAS No.:1269420-24-7
Molecular Formula:C₁₉H₂₀FN₅O₄S
Molecular Weight:433.463
Hs Code.:

Synonyms:4-amino-quinazoline-8-carboxylic acid [6-fluoro-2-methoxy-3-(propane-1-sulfonylamino)-phenyl]-amide

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Chemical Property of 4-amino-quinazoline-8-carboxylic acid [6-fluoro-2-methoxy-3-(propane-1-sulfonylamino)-phenyl]-amide

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Technology Process of 4-amino-quinazoline-8-carboxylic acid [6-fluoro-2-methoxy-3-(propane-1-sulfonylamino)-phenyl]-amide

There total 10 articles about 4-amino-quinazoline-8-carboxylic acid [6-fluoro-2-methoxy-3-(propane-1-sulfonylamino)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1269421-72-8
4-amino-N-(6-fluoro-2-methoxy-3-(N-(4-methoxybenzyl)(propylsulfonamido))-phenyl)quinazoline-8-carboxamide

: 1269420-24-7
4-amino-quinazoline-8-carboxylic acid [6-fluoro-2-methoxy-3-(propane-1-sulfonylamino)-phenyl]-amide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 83141-10-0
2,6-difluoro-3-nitrobenzoic acid

: 1269420-24-7
4-amino-quinazoline-8-carboxylic acid [6-fluoro-2-methoxy-3-(propane-1-sulfonylamino)-phenyl]-amide

Guidance literature:: Multi-step reaction with 10 steps

1.1: methanol / 2 h / Cooling with water bath

2.1: -4 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 60 h / 20 °C / 760.05 Torr / Inert atmosphere

4.1: dmap; pyridine / dichloromethane / 14.08 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Cooling with ice

5.2: 3 h / 20 °C / Cooling with ice

6.1: sodium hydroxide; water / tetrahydrofuran / 48 h / 60 °C

6.2: pH 2

7.1: triethylamine; diphenyl phosphoryl azide / 1,4-dioxane / 4 h / 20 °C / Inert atmosphere; Reflux

7.2: 2 h / Reflux

8.1: triethylamine / chloroform / 3.5 h / 60 °C

9.1: ammonia / 1,4-dioxane / 0.33 h / 120 °C / Microwave irradiation

10.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With pyridine; methanol; dmap; diphenyl phosphoryl azide; ammonia; water; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1268830-89-2
methyl 6-fluoro-2-methoxy-3-nitrobenzoate

: 1269420-24-7
4-amino-quinazoline-8-carboxylic acid [6-fluoro-2-methoxy-3-(propane-1-sulfonylamino)-phenyl]-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 60 h / 20 °C / 760.05 Torr / Inert atmosphere

2.1: dmap; pyridine / dichloromethane / 14.08 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Cooling with ice

3.2: 3 h / 20 °C / Cooling with ice

4.1: sodium hydroxide; water / tetrahydrofuran / 48 h / 60 °C

4.2: pH 2

5.1: triethylamine; diphenyl phosphoryl azide / 1,4-dioxane / 4 h / 20 °C / Inert atmosphere; Reflux

5.2: 2 h / Reflux

6.1: triethylamine / chloroform / 3.5 h / 60 °C

7.1: ammonia / 1,4-dioxane / 0.33 h / 120 °C / Microwave irradiation

8.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With pyridine; dmap; diphenyl phosphoryl azide; ammonia; water; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;