6-{2-[4-(4-trifluoromethylpyridin-2-yloxy)-phenyl]-ethoxy}-pyrimidine-4,5-diamine

Base Information

Chemical Name:6-{2-[4-(4-trifluoromethylpyridin-2-yloxy)-phenyl]-ethoxy}-pyrimidine-4,5-diamine
CAS No.:1268609-85-3
Molecular Formula:C₁₈H₁₆F₃N₅O₂
Molecular Weight:391.353
Hs Code.:

Synonyms:6-{2-[4-(4-trifluoromethylpyridin-2-yloxy)-phenyl]-ethoxy}-pyrimidine-4,5-diamine

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Chemical Property of 6-{2-[4-(4-trifluoromethylpyridin-2-yloxy)-phenyl]-ethoxy}-pyrimidine-4,5-diamine

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Technology Process of 6-{2-[4-(4-trifluoromethylpyridin-2-yloxy)-phenyl]-ethoxy}-pyrimidine-4,5-diamine

There total 4 articles about 6-{2-[4-(4-trifluoromethylpyridin-2-yloxy)-phenyl]-ethoxy}-pyrimidine-4,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268609-80-8
5-nitro-6-{2-[4-(4-trifluoromethylpyridin-2-yloxy)phenyl]ethoxy}pyrimidin-4-ylamine

: 1268609-85-3
6-{2-[4-(4-trifluoromethylpyridin-2-yloxy)-phenyl]-ethoxy}-pyrimidine-4,5-diamine

Guidance literature:: With hydrogen; 5% Pd(II)/C(eggshell); In ethanol; for 20h; under 2585.81 Torr;

Reference yield:

: 118078-66-3
2-fluoro-4-(trifluoromethyl) Pyridine

: 1268609-85-3
6-{2-[4-(4-trifluoromethylpyridin-2-yloxy)-phenyl]-ethoxy}-pyrimidine-4,5-diamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / dimethyl sulfoxide / 20 h / 25 °C

2.1: sodium hydride / dimethyl sulfoxide / 50 - 60 °C

2.2: 6 h / 45 °C

3.1: hydrogen / 5% Pd(II)/C(eggshell) / ethanol / 20 h / 2585.81 Torr

With hydrogen; sodium hydride; potassium carbonate; 5% Pd(II)/C(eggshell); In ethanol; dimethyl sulfoxide;

Reference yield:

: 1268609-79-5
2-[4-(4-trifluoromethylpyridin-2-yloxy)-phenyl]-ethanol

: 1268609-85-3
6-{2-[4-(4-trifluoromethylpyridin-2-yloxy)-phenyl]-ethoxy}-pyrimidine-4,5-diamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / dimethyl sulfoxide / 50 - 60 °C

1.2: 6 h / 45 °C

2.1: hydrogen / 5% Pd(II)/C(eggshell) / ethanol / 20 h / 2585.81 Torr

With hydrogen; sodium hydride; 5% Pd(II)/C(eggshell); In ethanol; dimethyl sulfoxide;