2-Fluoro-4-trifluoromethyl-pyridine

Base Information

Chemical Name:2-Fluoro-4-trifluoromethyl-pyridine
CAS No.:118078-66-3
Molecular Formula:C₆H₃F₄N
Molecular Weight:165.09
Hs Code.:2933399090
European Community (EC) Number:687-071-7
DSSTox Substance ID:DTXSID20457178
Nikkaji Number:J2.077.064C
Wikidata:Q72477570
Mol file:118078-66-3.mol

Synonyms:2-Fluoro-4-trifluoromethyl-pyridine;pyridine, 2-fluoro-4-(trifluoromethyl)-;

Suppliers and Price of 2-Fluoro-4-trifluoromethyl-pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Fluoro-4-(trifluoromethyl)pyridine
500mg
$ 65.00

TRC
2-Fluoro-4-(trifluoromethyl)pyridine
100mg
$ 45.00

TCI Chemical
2-Fluoro-4-(trifluoromethyl)pyridine >98.0%(GC)
5g
$ 222.00

TCI Chemical
2-Fluoro-4-(trifluoromethyl)pyridine >98.0%(GC)
1g
$ 74.00

SynQuest Laboratories
2-Fluoro-4-trifluoromethylpyridine 95%
1 g
$ 39.00

SynQuest Laboratories
2-Fluoro-4-trifluoromethylpyridine 95%
5 g
$ 135.00

Sigma-Aldrich
2-Fluoro-4-(trifluoromethyl)pyridine ≥94%
1g
$ 65.40

Matrix Scientific
2-Fluoro-4-(trifluoromethyl)pyridine 97%
1g
$ 14.00

Matrix Scientific
2-Fluoro-4-(trifluoromethyl)pyridine 97%
5g
$ 54.00

Matrix Scientific
2-Fluoro-4-(trifluoromethyl)pyridine 97%
25g
$ 168.00

Total 71 raw suppliers

Chemical Property of 2-Fluoro-4-trifluoromethyl-pyridine

Chemical Property:

Vapor Pressure:5.48mmHg at 25°C
Refractive Index:1.402
Boiling Point:147.936 °C at 760 mmHg
PKA:-2.79±0.10(Predicted)
Flash Point:43.271 °C
PSA：12.89000
Density:1.371 g/cm³
LogP:2.23950
Storage Temp.:Refrigerated.
Water Solubility.:Miscible with water, alcohol, acetonitrile and N,N-dimethylformamide
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:165.02016175
Heavy Atom Count:11
Complexity:133

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-4-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi,T
Statements: 10-25-36/37/38
Safety Statements: 26-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN=C(C=C1C(F)(F)F)F
Uses Reactant for: Preparation of aminopyridines via amination reactions Catalytic ligand for: ? Regioselective preparation of tetramethylbiphenyls via aerobic oxidative coupling of xylene catalyzed by palladium 2-Fluoro-4-(trifluoromethyl)pyridine acts as a reactant in the preparation of aminopyridines through amination reactions. It is also used as a catalytic ligand for regioselective preparation of tetramethylbiphenyls through aerobic oxidative coupling of xylene catalyzed by palladium.

Technology Process of 2-Fluoro-4-trifluoromethyl-pyridine

There total 2 articles about 2-Fluoro-4-trifluoromethyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1895006-01-5
dimesityl(trifluoromethyl)sulfonium trifluoromethanesulfonate

: 128071-98-7
4-bromo-2-fluoropyridine

: 118078-66-3
2-fluoro-4-(trifluoromethyl) Pyridine

Guidance literature:: With dilithium tetrabromocuprate; 1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)-2-trisilanol; Ir(2-(2,4-difluorophenyl)-5-fluoropyridine)₂(4,4'-di(trifluoromethyl)-2,2'-bipyridyl)PF₆; sodium carbonate; In acetone; at 35 ℃; Irradiation;
DOI:10.1126/science.aat4133