2-(p-trifluoroacetamidophenyl)ethyl 4-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl)-2,3-diacetamido-6-O-benzyl-2,3-dideoxy-α-D-mannopyranoside

Base Information

Chemical Name:2-(p-trifluoroacetamidophenyl)ethyl 4-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl)-2,3-diacetamido-6-O-benzyl-2,3-dideoxy-α-D-mannopyranoside
CAS No.:297733-60-9
Molecular Formula:C₄₁H₅₁F₃N₄O₁₅
Molecular Weight:896.869
Hs Code.:

2-(p-trifluoroacetamidophenyl)ethyl 4-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl)-2,3-diacetamido-6-O-benzyl-2,3-dideoxy-α-D-mannopyranoside

Synonyms:2-(p-trifluoroacetamidophenyl)ethyl 4-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl)-2,3-diacetamido-6-O-benzyl-2,3-dideoxy-α-D-mannopyranoside

Suppliers and Price of 2-(p-trifluoroacetamidophenyl)ethyl 4-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl)-2,3-diacetamido-6-O-benzyl-2,3-dideoxy-α-D-mannopyranoside

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(p-trifluoroacetamidophenyl)ethyl 4-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl)-2,3-diacetamido-6-O-benzyl-2,3-dideoxy-α-D-mannopyranoside

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(p-trifluoroacetamidophenyl)ethyl 4-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl)-2,3-diacetamido-6-O-benzyl-2,3-dideoxy-α-D-mannopyranoside

There total 9 articles about 2-(p-trifluoroacetamidophenyl)ethyl 4-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl)-2,3-diacetamido-6-O-benzyl-2,3-dideoxy-α-D-mannopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 108-24-7
acetic anhydride

: 1043887-04-2
ethyl 3,4,6-tri-O-acetyl-2-azido-2-deoxy-1-thio-α-D-glucopyranoside

: 297733-58-5
2-(p-trifluoroacetamidophenyl)ethyl 2,3-diazido-6-O-benzyl-2,3-dideoxy-α-D-mannopyranoside

: 297733-60-9
2-(p-trifluoroacetamidophenyl)ethyl 4-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl)-2,3-diacetamido-6-O-benzyl-2,3-dideoxy-α-D-mannopyranoside

Guidance literature:: ethyl 3,4,6-tri-O-acetyl-2-azido-2-deoxy-1-thio-α-D-glucopyranoside; 2-(p-trifluoroacetamidophenyl)ethyl 2,3-diazido-6-O-benzyl-2,3-dideoxy-α-D-mannopyranoside; With 2,6-di-tert-butyl-4-methylpyridine; 4 A molecular sieve; dimethyl-(methylthio)-sulphonium trifluoromethanesulphonate; In dichloromethane; at 20 ℃; for 14h;

With hydrogen sulfide; triethylamine; In pyridine; water; for 1.91667h;

acetic anhydride; In pyridine; for 1.5h;
DOI:10.1016/S0008-6215(99)00318-3

Reference yield:

: 20701-61-5,56119-28-9,131564-36-8,142924-31-0,151123-92-1,141899-53-8
ethyl 4,6-O-benzylidene-1-thio-β-D-glucopyranoside

: 297733-60-9
2-(p-trifluoroacetamidophenyl)ethyl 4-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl)-2,3-diacetamido-6-O-benzyl-2,3-dideoxy-α-D-mannopyranoside

Guidance literature:: Multi-step reaction with 8 steps

1.1: 50 percent / pyridine / 70 h / 20 °C

2.1: Bu₄NHSO₄; NaOH; K₂CO₃ / toluene; dimethylsulfoxide; butan-1-ol / 2 h / 20 °C

3.1: NaN₃; NH₄Cl / dimethylsulfoxide / 20 h / 80 °C

4.1: CH₂Cl₂; pyridine / 2.5 h / 0 - 20 °C

5.1: NaN₃ / dimethylsulfoxide / 0.5 h / 20 °C

6.1: 44 percent / 4 Angstroem molecular sieves; dimethyl(thiomethyl)sulfonium triflate / CH₂Cl₂ / 70 h / 20 °C

7.1: 73 percent / sodium cyanoborohydride; 3 Angstroem molecular sieves; fluoroboric acid / tetrahydrofuran; diethyl ether / 4 h / 0 °C

8.1: 2,6-di-tert-butyl-4-methylpyridine; 4 Angstroem molecular sieves; dimethyl(thiomethyl)sulfonium triflate / CH₂Cl₂ / 14 h / 20 °C

8.2: H₂S; Et₃N / pyridine; H₂O / 1.92 h

8.3: 40 percent / pyridine / 1.5 h

With sodium hydroxide; tetrafluoroboric acid; sodium azide; 2,6-di-tert-butyl-4-methylpyridine; 3 A molecular sieve; 4 A molecular sieve; tetra(n-butyl)ammonium hydrogensulfate; sodium cyanoborohydride; potassium carbonate; ammonium chloride; dimethyl-(methylthio)-sulphonium trifluoromethanesulphonate; In tetrahydrofuran; pyridine; diethyl ether; dichloromethane; dimethyl sulfoxide; toluene; butan-1-ol; 1.1: Tosylation / 2.1: Substitution / 3.1: Substitution / 4.1: Acylation / 5.1: Substitution / 6.1: glycosylation / 7.1: Reduction / 8.1: glycosylation / 8.2: Reduction / 8.3: Acetylation;
DOI:10.1016/S0008-6215(99)00318-3

Reference yield:

: 115166-92-2
2-[4-(trifluoroacetylamino)phenyl]ethanol

: 297733-60-9
2-(p-trifluoroacetamidophenyl)ethyl 4-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl)-2,3-diacetamido-6-O-benzyl-2,3-dideoxy-α-D-mannopyranoside

Guidance literature:: Multi-step reaction with 3 steps

1.1: 44 percent / 4 Angstroem molecular sieves; dimethyl(thiomethyl)sulfonium triflate / CH₂Cl₂ / 70 h / 20 °C

2.1: 73 percent / sodium cyanoborohydride; 3 Angstroem molecular sieves; fluoroboric acid / tetrahydrofuran; diethyl ether / 4 h / 0 °C

3.1: 2,6-di-tert-butyl-4-methylpyridine; 4 Angstroem molecular sieves; dimethyl(thiomethyl)sulfonium triflate / CH₂Cl₂ / 14 h / 20 °C

3.2: H₂S; Et₃N / pyridine; H₂O / 1.92 h

3.3: 40 percent / pyridine / 1.5 h

With tetrafluoroboric acid; 2,6-di-tert-butyl-4-methylpyridine; 3 A molecular sieve; 4 A molecular sieve; sodium cyanoborohydride; dimethyl-(methylthio)-sulphonium trifluoromethanesulphonate; In tetrahydrofuran; diethyl ether; dichloromethane; 1.1: glycosylation / 2.1: Reduction / 3.1: glycosylation / 3.2: Reduction / 3.3: Acetylation;
DOI:10.1016/S0008-6215(99)00318-3