methyl (S)-2-benzyloxycarbonylamino-3-(2-methylthio-3-indolyl)propanoate

Base Information

• Chemical Name: methyl (S)-2-benzyloxycarbonylamino-3-(2-methylthio-3-indolyl)propanoate
• CAS No.: 96838-38-9
• Molecular Formula: C₂₁H₂₂N₂O₄S
• Molecular Weight: 398.483
• Mol file: 96838-38-9.mol

Synonyms:methyl (S)-2-benzyloxycarbonylamino-3-(2-methylthio-3-indolyl)propanoate

Chemical Property of methyl (S)-2-benzyloxycarbonylamino-3-(2-methylthio-3-indolyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (S)-2-benzyloxycarbonylamino-3-(2-methylthio-3-indolyl)propanoate

There total 5 articles about methyl (S)-2-benzyloxycarbonylamino-3-(2-methylthio-3-indolyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (S)-2-benzyloxycarbonylamino-3-((RS)-2-oxo-3-indolinyl)propanoate (96838-37-8,110527-68-9,110527-70-3) → methyl (S)-2-benzyloxycarbonylamino-3-(2-methylthio-3-indolyl)propanoate (96838-38-9)

Guidance literature:

Multi-step reaction with 2 steps

1: P₂S₅ / pyridine / 3 h / Heating

2: potassium carbonate / acetone / 5 h / Ambient temperature

With tetraphosphorus decasulfide; potassium carbonate; In pyridine; acetone;

DOI:10.1016/S0040-4020(01)96070-3

Reference yield:

(S)-2-(((benzyloxy)carbonyl)amino)-3-(2-oxoindolin-3-yl)propanoic acid (911675-22-4) → methyl (S)-2-benzyloxycarbonylamino-3-(2-methylthio-3-indolyl)propanoate (96838-38-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / HCl / Ambient temperature

2: P₂S₅ / pyridine / 3 h / Heating

3: potassium carbonate / acetone / 5 h / Ambient temperature

With hydrogenchloride; tetraphosphorus decasulfide; potassium carbonate; In pyridine; acetone;

DOI:10.1016/S0040-4020(01)96070-3

Reference yield:

methyl 2-benzyloxycarbonylamino-3-(2-thioxo-3-indolinyl)propanoate (110527-66-7) + methyl iodide (74-88-4) → methyl (S)-2-benzyloxycarbonylamino-3-(2-methylthio-3-indolyl)propanoate (96838-38-9)

Guidance literature:

With potassium carbonate; In acetone; for 5h; Yield given; Ambient temperature;

DOI:10.1016/S0040-4020(01)96070-3

upstream raw materials:

methyl (S)-2-benzyloxycarbonylamino-3-((RS)-2-oxo-3-indolinyl)propanoate

methyl iodide

methyl 2-benzyloxycarbonylamino-3-(2-thioxo-3-indolinyl)propanoate

(S)-2-(((benzyloxy)carbonyl)amino)-3-(2-oxoindolin-3-yl)propanoic acid

Downstream raw materials:

(S)-2-benzyloxycarbonylamino-3-(2-methylthio-3-indolyl)propanoic acid

(R)-2-[(S)-2-Benzyloxycarbonylamino-3-(2-methylsulfanyl-1H-indol-3-yl)-propionylamino]-3-(2-methylsulfanyl-1H-indol-3-yl)-propionic acid methyl ester