1-(2,4-difluorophenyl)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Base Information

• Chemical Name: 1-(2,4-difluorophenyl)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
• CAS No.: 108138-27-8
• Molecular Formula: C20H16 F3 N3 O3
• Molecular Weight: 403.361
• Mol file: 108138-27-8.mol

Synonyms:A 57531; A62251; PD 137954; T 1814

Chemical Property of 1-(2,4-difluorophenyl)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 8.74E-16mmHg at 25°C
• Boiling Point: 611°C at 760 mmHg
• Flash Point: 323.3°C
• Density: 1.48g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2,4-difluorophenyl)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

There total 10 articles about 1-(2,4-difluorophenyl)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

piperazine (110-85-0) + 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid (98105-93-2) → A 57531 (108138-27-8)

Guidance literature:

In dimethyl sulfoxide; at 120 ℃; for 6h;

Reference yield: 46.0%

piperazine (110-85-0) + 6,7-difluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid (103995-01-3) → A 57531 (108138-27-8)

Guidance literature:

In acetonitrile;

DOI:10.1021/jm00015a021

Reference yield:

piperazine (110-85-0) + methyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate → A 57531 (108138-27-8)

Guidance literature:

piperazine; methyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate; In isopropyl alcohol; at 130 ℃; for 3h;

With sodium hydroxide; at 90 ℃; for 1.5h;

DOI:10.1248/cpb.c17-00035

upstream raw materials:

piperazine

6,7-difluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid

2,4-difluorophenylamine

2,4,5-trifluorobenzoic acid