4-Hydroxy-4-methyl-2-[1-phenylsulfanyl-meth-(E)-ylidene]-pentanoic acid tert-butylamide

Base Information

Chemical Name:4-Hydroxy-4-methyl-2-[1-phenylsulfanyl-meth-(E)-ylidene]-pentanoic acid tert-butylamide
CAS No.:87531-49-5
Molecular Formula:C₁₇H₂₅NO₂S
Molecular Weight:307.457
Hs Code.:

Synonyms:4-Hydroxy-4-methyl-2-[1-phenylsulfanyl-meth-(E)-ylidene]-pentanoic acid tert-butylamide

Suppliers and Price of 4-Hydroxy-4-methyl-2-[1-phenylsulfanyl-meth-(E)-ylidene]-pentanoic acid tert-butylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Hydroxy-4-methyl-2-[1-phenylsulfanyl-meth-(E)-ylidene]-pentanoic acid tert-butylamide

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Technology Process of 4-Hydroxy-4-methyl-2-[1-phenylsulfanyl-meth-(E)-ylidene]-pentanoic acid tert-butylamide

There total 3 articles about 4-Hydroxy-4-methyl-2-[1-phenylsulfanyl-meth-(E)-ylidene]-pentanoic acid tert-butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 87531-40-6
(E)-N-t-butyl-2-methyl-3-(phenylthio)propenamide

: 67-64-1
acetone

: 87531-49-5
4-Hydroxy-4-methyl-2-[1-phenylsulfanyl-meth-(E)-ylidene]-pentanoic acid tert-butylamide

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; 1.) -80- -70 deg C, 1.5 h; 2.) -45- -25 deg C, 1.5 h;
DOI:10.1246/cl.1983.1065

Reference yield:

: 1078-67-7
(E)-2-Methyl-3-phenylsulfanyl-acryloyl chloride

: 87531-49-5
4-Hydroxy-4-methyl-2-[1-phenylsulfanyl-meth-(E)-ylidene]-pentanoic acid tert-butylamide

Guidance literature:: Multi-step reaction with 2 steps

2: 80 percent / LDA / tetrahydrofuran / 1.) -80- -70 deg C, 1.5 h; 2.) -45- -25 deg C, 1.5 h

With lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1246/cl.1983.1065

Reference yield:

: 2-Phenylsulfanylmethyl-acryloyl chloride

: 87531-49-5
4-Hydroxy-4-methyl-2-[1-phenylsulfanyl-meth-(E)-ylidene]-pentanoic acid tert-butylamide

Guidance literature:: Multi-step reaction with 2 steps

2: LDA / tetrahydrofuran / 1.) -80- -70 deg C, 1.5 h; 2.) -45- -25 deg C, 1.5 h

With lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1246/cl.1983.1065