2-(2-(3-cyclopropylphenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

Base Information

Chemical Name:2-(2-(3-cyclopropylphenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine
CAS No.:1417343-25-9
Molecular Formula:C₂₃H₂₀N₆
Molecular Weight:380.452
Hs Code.:

Synonyms:2-(2-(3-cyclopropylphenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

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Chemical Property of 2-(2-(3-cyclopropylphenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

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Technology Process of 2-(2-(3-cyclopropylphenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

There total 6 articles about 2-(2-(3-cyclopropylphenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.1%

: 1417343-24-8
2-(2-(3-bromophenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

: 411235-57-9
cyclopropylboronic acid

: 1417343-25-9
2-(2-(3-cyclopropylphenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

Guidance literature:: With potassium phosphate; palladium diacetate; tricyclohexylphosphine; In water; toluene; at 110 ℃; for 16h; Inert atmosphere; Sealed tube;

Reference yield:

: 1417343-29-3
2-((tert-butoxycarbonyl)amino)isonicotinic acid hydrochloride

: 1417343-25-9
2-(2-(3-cyclopropylphenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C / Sealed tube

1.2: 17 h / 65 °C

2.1: N-ethyl-N,N-diisopropylamine / ethanol / 90 °C / Sealed tube

3.1: potassium phosphate; palladium diacetate; tricyclohexylphosphine / water; toluene / 16 h / 110 °C / Inert atmosphere; Sealed tube

With potassium phosphate; palladium diacetate; N-ethyl-N,N-diisopropylamine; HATU; tricyclohexylphosphine; In ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 639091-75-1,470463-38-8
methyl 2-[(tert-butoxycarbonyl)amino]isonicotinate

: 1417343-25-9
2-(2-(3-cyclopropylphenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / methanol / 0.17 h / 50 °C

1.2: 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C / Sealed tube

2.2: 17 h / 65 °C

3.1: N-ethyl-N,N-diisopropylamine / ethanol / 90 °C / Sealed tube

4.1: potassium phosphate; palladium diacetate; tricyclohexylphosphine / water; toluene / 16 h / 110 °C / Inert atmosphere; Sealed tube

With potassium phosphate; palladium diacetate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; tricyclohexylphosphine; In methanol; ethanol; water; N,N-dimethyl-formamide; toluene;