(S)-4-oxo-4-(6-oxo-5-(4-((2-sulfamoylbenzo[d]thiazol-6-yloxy)methyl)-1H-1,2,3-triazol-1-yl)-6-(4-(trifluoromethyl)benzylamino)hexylamino)butanoic acid

Base Information

Chemical Name:(S)-4-oxo-4-(6-oxo-5-(4-((2-sulfamoylbenzo[d]thiazol-6-yloxy)methyl)-1H-1,2,3-triazol-1-yl)-6-(4-(trifluoromethyl)benzylamino)hexylamino)butanoic acid
CAS No.:1071471-12-9
Molecular Formula:C₂₈H₃₀F₃N₇O₇S₂
Molecular Weight:697.716
Hs Code.:

Synonyms:(S)-4-oxo-4-(6-oxo-5-(4-((2-sulfamoylbenzo[d]thiazol-6-yloxy)methyl)-1H-1,2,3-triazol-1-yl)-6-(4-(trifluoromethyl)benzylamino)hexylamino)butanoic acid

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Chemical Property of (S)-4-oxo-4-(6-oxo-5-(4-((2-sulfamoylbenzo[d]thiazol-6-yloxy)methyl)-1H-1,2,3-triazol-1-yl)-6-(4-(trifluoromethyl)benzylamino)hexylamino)butanoic acid

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Technology Process of (S)-4-oxo-4-(6-oxo-5-(4-((2-sulfamoylbenzo[d]thiazol-6-yloxy)methyl)-1H-1,2,3-triazol-1-yl)-6-(4-(trifluoromethyl)benzylamino)hexylamino)butanoic acid

There total 9 articles about (S)-4-oxo-4-(6-oxo-5-(4-((2-sulfamoylbenzo[d]thiazol-6-yloxy)methyl)-1H-1,2,3-triazol-1-yl)-6-(4-(trifluoromethyl)benzylamino)hexylamino)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1071474-90-2
6-(prop-2-ynyloxy)benzo[d]thiazole-2-sulfonamide

: 1071476-35-1
(S)-4-(5-azido-6-oxo-6-(4-(trifluoromethyl)benzylamino)hexylamino)-4-oxobutanoic acid

: 1071471-12-9
(S)-4-oxo-4-(6-oxo-5-(4-((2-sulfamoylbenzo[d]thiazol-6-yloxy)methyl)-1H-1,2,3-triazol-1-yl)-6-(4-(trifluoromethyl)benzylamino)hexylamino)butanoic acid

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In tetrahydrofuran; water; tert-butyl alcohol; for 12h;

Reference yield:

: 333366-32-8
(S)-2-azido-6-((tert-butoxycarbonyl)amino)hexanoic acid

: 1071471-12-9
(S)-4-oxo-4-(6-oxo-5-(4-((2-sulfamoylbenzo[d]thiazol-6-yloxy)methyl)-1H-1,2,3-triazol-1-yl)-6-(4-(trifluoromethyl)benzylamino)hexylamino)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 12 h

2.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 0 - 20 °C

3.1: dmap / 5 h / 20 °C

4.1: copper(II) sulfate; sodium L-ascorbate / tetrahydrofuran; water; tert-butyl alcohol / 12 h

With hydrogenchloride; benzotriazol-1-ol; copper(II) sulfate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium L-ascorbate; dmap; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1071476-34-0
(S)-tert-butyl 5-azido-6-oxo-6-(4-(trifluoromethyl)benzylamino)hexylcarbamate

: 1071471-12-9
(S)-4-oxo-4-(6-oxo-5-(4-((2-sulfamoylbenzo[d]thiazol-6-yloxy)methyl)-1H-1,2,3-triazol-1-yl)-6-(4-(trifluoromethyl)benzylamino)hexylamino)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 2.5 h / 0 - 20 °C

2: dmap / 5 h / 20 °C

3: copper(II) sulfate; sodium L-ascorbate / tetrahydrofuran; water; tert-butyl alcohol / 12 h

With hydrogenchloride; copper(II) sulfate; sodium L-ascorbate; dmap; In tetrahydrofuran; 1,4-dioxane; water; tert-butyl alcohol;