4-pyridin-2-yl-2-triethylsilanyloxymethyl-1-[4-(trityl-amino)-phenyl]-butan-2-ol

Base Information

Chemical Name:4-pyridin-2-yl-2-triethylsilanyloxymethyl-1-[4-(trityl-amino)-phenyl]-butan-2-ol
CAS No.:223438-16-2
Molecular Formula:C₄₁H₄₈N₂O₂Si
Molecular Weight:628.93
Hs Code.:

Synonyms:4-pyridin-2-yl-2-triethylsilanyloxymethyl-1-[4-(trityl-amino)-phenyl]-butan-2-ol

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Chemical Property of 4-pyridin-2-yl-2-triethylsilanyloxymethyl-1-[4-(trityl-amino)-phenyl]-butan-2-ol

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Technology Process of 4-pyridin-2-yl-2-triethylsilanyloxymethyl-1-[4-(trityl-amino)-phenyl]-butan-2-ol

There total 7 articles about 4-pyridin-2-yl-2-triethylsilanyloxymethyl-1-[4-(trityl-amino)-phenyl]-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 994-30-9
triethylsilyl chloride

: 223438-16-2
4-pyridin-2-yl-2-triethylsilanyloxymethyl-1-[4-(trityl-amino)-phenyl]-butan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / Et₃N, DMAP / tetrahydrofuran / 3 h / Ambient temperature

2: 95 percent / m-CPBA / CH₂Cl₂ / 1.) reflux, 3 h, 2.) room temperature, 3 h

3: H₂ / Pd/C / ethyl acetate / 4 h / 760 Torr / Ambient temperature

4: Et₃N / CH₂Cl₂ / 1 h / 0 °C

5: 1.) PhLi / 1.) Et₂O, cyclohexane, room temperature, 1 h, 2.) Et₂O, 3 h

With dmap; hydrogen; phenyllithium; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/S0968-0896(98)00203-X

Reference yield:

: 223438-11-7
2-(4-nitrobenzyl)prop-2-en-1-ol

: 223438-16-2
4-pyridin-2-yl-2-triethylsilanyloxymethyl-1-[4-(trityl-amino)-phenyl]-butan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / Et₃N, DMAP / tetrahydrofuran / 3 h / Ambient temperature

2: 95 percent / m-CPBA / CH₂Cl₂ / 1.) reflux, 3 h, 2.) room temperature, 3 h

3: H₂ / Pd/C / ethyl acetate / 4 h / 760 Torr / Ambient temperature

4: Et₃N / CH₂Cl₂ / 1 h / 0 °C

5: 1.) PhLi / 1.) Et₂O, cyclohexane, room temperature, 1 h, 2.) Et₂O, 3 h

With dmap; hydrogen; phenyllithium; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/S0968-0896(98)00203-X

Reference yield:

: 223438-10-6
ethyl 2-<(4-nitrophenyl)methyl>-acrylate

: 223438-16-2
4-pyridin-2-yl-2-triethylsilanyloxymethyl-1-[4-(trityl-amino)-phenyl]-butan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / DIBAL-H / tetrahydrofuran; hexane / 1 h / -78 °C

2: 100 percent / Et₃N, DMAP / tetrahydrofuran / 3 h / Ambient temperature

3: 95 percent / m-CPBA / CH₂Cl₂ / 1.) reflux, 3 h, 2.) room temperature, 3 h

4: H₂ / Pd/C / ethyl acetate / 4 h / 760 Torr / Ambient temperature

5: Et₃N / CH₂Cl₂ / 1 h / 0 °C

6: 1.) PhLi / 1.) Et₂O, cyclohexane, room temperature, 1 h, 2.) Et₂O, 3 h

With dmap; hydrogen; diisobutylaluminium hydride; phenyllithium; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate;
DOI:10.1016/S0968-0896(98)00203-X