2-{2-[5-(tert-butoxycarbonyl)furan-2-yl]ethynyl}-N-ethynyl-N-tosyl-benzenamine

Base Information

Chemical Name:2-{2-[5-(tert-butoxycarbonyl)furan-2-yl]ethynyl}-N-ethynyl-N-tosyl-benzenamine
CAS No.:1311149-84-4
Molecular Formula:C₂₆H₂₃NO₅S
Molecular Weight:461.538
Hs Code.:

Synonyms:2-{2-[5-(tert-butoxycarbonyl)furan-2-yl]ethynyl}-N-ethynyl-N-tosyl-benzenamine

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Chemical Property of 2-{2-[5-(tert-butoxycarbonyl)furan-2-yl]ethynyl}-N-ethynyl-N-tosyl-benzenamine

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Technology Process of 2-{2-[5-(tert-butoxycarbonyl)furan-2-yl]ethynyl}-N-ethynyl-N-tosyl-benzenamine

There total 3 articles about 2-{2-[5-(tert-butoxycarbonyl)furan-2-yl]ethynyl}-N-ethynyl-N-tosyl-benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1311149-81-1
2-({2-[5-(tert-butoxycarbonyl)furan-2-yl]}ethynyl)-N-[2-(trimethylsilyl)ethynyl]-N-tosyl-benzenamine

: 1311149-84-4
2-{2-[5-(tert-butoxycarbonyl)furan-2-yl]ethynyl}-N-ethynyl-N-tosyl-benzenamine

Guidance literature:: With tetrabutyl ammonium fluoride; water; In tetrahydrofuran; at 0 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201100121

Reference yield:

: 585-70-6
5-bromo-furan-2-carboxylic acid

: 1311149-84-4
2-{2-[5-(tert-butoxycarbonyl)furan-2-yl]ethynyl}-N-ethynyl-N-tosyl-benzenamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C / Inert atmosphere

2.2: 22 °C / Inert atmosphere

2.3: 22 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 0 °C / Inert atmosphere

With dmap; tetrabutyl ammonium fluoride; water; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1002/ejoc.201100121

Reference yield:

: 59862-83-8
tert-butyl 5-bromofuran-2-carboxylate

: 1311149-84-4
2-{2-[5-(tert-butoxycarbonyl)furan-2-yl]ethynyl}-N-ethynyl-N-tosyl-benzenamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C / Inert atmosphere

1.2: 22 °C / Inert atmosphere

1.3: 22 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 0 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; water; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1002/ejoc.201100121