methyl 1-(5-(tert-butoxycarbonyl)furan-2-yl)-5-tosyl-5H-pyrido[4,3-b]indole-3-carboxylate

Base Information

Chemical Name:methyl 1-(5-(tert-butoxycarbonyl)furan-2-yl)-5-tosyl-5H-pyrido[4,3-b]indole-3-carboxylate
CAS No.:1311149-92-4
Molecular Formula:C₂₉H₂₆N₂O₇S
Molecular Weight:546.601
Hs Code.:

Synonyms:methyl 1-(5-(tert-butoxycarbonyl)furan-2-yl)-5-tosyl-5H-pyrido[4,3-b]indole-3-carboxylate

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Chemical Property of methyl 1-(5-(tert-butoxycarbonyl)furan-2-yl)-5-tosyl-5H-pyrido[4,3-b]indole-3-carboxylate

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Technology Process of methyl 1-(5-(tert-butoxycarbonyl)furan-2-yl)-5-tosyl-5H-pyrido[4,3-b]indole-3-carboxylate

There total 5 articles about methyl 1-(5-(tert-butoxycarbonyl)furan-2-yl)-5-tosyl-5H-pyrido[4,3-b]indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 17640-15-2
methyl cyanoformate

: 1311149-84-4
2-{2-[5-(tert-butoxycarbonyl)furan-2-yl]ethynyl}-N-ethynyl-N-tosyl-benzenamine

: 1311149-92-4
methyl 1-(5-(tert-butoxycarbonyl)furan-2-yl)-5-tosyl-5H-pyrido[4,3-b]indole-3-carboxylate

Guidance literature:: With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In dichloromethane; at 40 ℃; for 6h; Inert atmosphere;
DOI:10.1002/ejoc.201100121

Reference yield: 36.0%

: 17640-15-2
methyl cyanoformate

: 1311149-84-4
2-{2-[5-(tert-butoxycarbonyl)furan-2-yl]ethynyl}-N-ethynyl-N-tosyl-benzenamine

: 1311149-87-7
methyl 4-[5-(tert-butoxycarbonyl)furan-2-yl]-9-tosyl-9H-pyrido[3,4-b]indole-3-carboxylate

: 1311149-92-4
methyl 1-(5-(tert-butoxycarbonyl)furan-2-yl)-5-tosyl-5H-pyrido[4,3-b]indole-3-carboxylate

Guidance literature:: With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; at 60 ℃; for 3h; Inert atmosphere;
DOI:10.1002/ejoc.201100121

Reference yield:

: 59862-83-8
tert-butyl 5-bromofuran-2-carboxylate

: 1311149-92-4
methyl 1-(5-(tert-butoxycarbonyl)furan-2-yl)-5-tosyl-5H-pyrido[4,3-b]indole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C / Inert atmosphere

1.2: 22 °C / Inert atmosphere

1.3: 22 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 0 °C / Inert atmosphere

3.1: bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tetrahydrofuran / 3 h / 60 °C / Inert atmosphere

With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; tetrabutyl ammonium fluoride; water; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1002/ejoc.201100121