5-hydroxy-3-p-tolyl-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide

Base Information

• Chemical Name: 5-hydroxy-3-p-tolyl-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide
• CAS No.: 219986-59-1
• Molecular Formula: C₁₂H₁₂F₃N₃OS
• Molecular Weight: 303.308
• Mol file: 219986-59-1.mol

Synonyms:5-hydroxy-3-p-tolyl-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide

Chemical Property of 5-hydroxy-3-p-tolyl-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-hydroxy-3-p-tolyl-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide

There total 1 articles about 5-hydroxy-3-p-tolyl-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

thiosemicarbazide (79-19-6) + 1,1,1-trifluoro-4-methoxy-4-(4-methylphenyl)-3-buten-2-one (187812-31-3) → 5-hydroxy-3-p-tolyl-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide (219986-59-1)

Guidance literature:

In methanol; at 40 - 45 ℃; for 20h;

DOI:10.1016/S0022-1139(98)00242-5

Reference yield: 80.0%

methylhydrazine (60-34-4) + 5-hydroxy-3-p-tolyl-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide (219986-59-1) → 2-methyl-5-p-tolyl-3-trifluoromethyl-3,4-dihydro-2H-pyrazol-3-ol

Guidance literature:

In tetrahydrofuran; at 20 - 25 ℃; for 7h;

DOI:10.1080/00397910008087174

Reference yield: 75.0%

5-hydroxy-3-p-tolyl-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide (219986-59-1) → 3-p-tolyl-5-(trifluormethyl)-1H-pyrazole (219986-64-8,948293-46-7)

Guidance literature:

With sulfuric acid; for 4h; Heating;

DOI:10.1016/S0022-1139(98)00242-5

upstream raw materials:

thiosemicarbazide

1,1,1-trifluoro-4-methoxy-4-(4-methylphenyl)-3-buten-2-one

Downstream raw materials:

3-p-tolyl-5-(trifluormethyl)-1H-pyrazole