1-(4-fluorophenyl)-2-(1,2,4-triazol-1-yl)-1-[1-[5-(trifluoromethyl)-2-pyridyl]cyclopropyl]ethanol

Base Information

Chemical Name:1-(4-fluorophenyl)-2-(1,2,4-triazol-1-yl)-1-[1-[5-(trifluoromethyl)-2-pyridyl]cyclopropyl]ethanol
CAS No.:1621276-89-8
Molecular Formula:C₁₉H₁₆F₄N₄O
Molecular Weight:392.356
Hs Code.:

Synonyms:1-(4-fluorophenyl)-2-(1,2,4-triazol-1-yl)-1-[1-[5-(trifluoromethyl)-2-pyridyl]cyclopropyl]ethanol

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Chemical Property of 1-(4-fluorophenyl)-2-(1,2,4-triazol-1-yl)-1-[1-[5-(trifluoromethyl)-2-pyridyl]cyclopropyl]ethanol

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Technology Process of 1-(4-fluorophenyl)-2-(1,2,4-triazol-1-yl)-1-[1-[5-(trifluoromethyl)-2-pyridyl]cyclopropyl]ethanol

There total 4 articles about 1-(4-fluorophenyl)-2-(1,2,4-triazol-1-yl)-1-[1-[5-(trifluoromethyl)-2-pyridyl]cyclopropyl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288-88-0
1,2,4-Triazole

: 1621282-82-3
2-[1-[2-(4-fluorophenyl)oxiran-2-yl]cyclopropyl]-5-(trifluoromethyl)pyridine

: 1621276-89-8
1-(4-fluorophenyl)-2-(1,2,4-triazol-1-yl)-1-[1-[5-(trifluoromethyl)-2-pyridyl]cyclopropyl]ethanol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield:

: 145834-67-9
1-(4-fluorophenyl)-2-[5-(trifluoromethyl)-2-pyridyl]ethanone

: 1621276-89-8
1-(4-fluorophenyl)-2-(1,2,4-triazol-1-yl)-1-[1-[5-(trifluoromethyl)-2-pyridyl]cyclopropyl]ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic anhydride / 0.08 h / 0 °C

2.1: sodium hydride / mineral oil; dimethyl sulfoxide / 0.75 h

2.2: 24 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C

With acetic anhydride; sodium hydride; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 1621276-89-8
1-(4-fluorophenyl)-2-(1,2,4-triazol-1-yl)-1-[1-[5-(trifluoromethyl)-2-pyridyl]cyclopropyl]ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 10.17 h / 55 °C / Reflux

2.1: acetic anhydride / 0.08 h / 0 °C

3.1: sodium hydride / mineral oil; dimethyl sulfoxide / 0.75 h

3.2: 24 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C

With acetic anhydride; sodium hydride; potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;