N-{(R)-2-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-ethyl}-4-(4-methoxymethoxy-phenyl)-butyramide

Base Information

Chemical Name:N-{(R)-2-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-ethyl}-4-(4-methoxymethoxy-phenyl)-butyramide
CAS No.:205587-48-0
Molecular Formula:C₃₂H₅₃NO₆Si₂
Molecular Weight:603.947
Hs Code.:

Synonyms:N-{(R)-2-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-ethyl}-4-(4-methoxymethoxy-phenyl)-butyramide

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Chemical Property of N-{(R)-2-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-ethyl}-4-(4-methoxymethoxy-phenyl)-butyramide

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Technology Process of N-{(R)-2-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-ethyl}-4-(4-methoxymethoxy-phenyl)-butyramide

There total 11 articles about N-{(R)-2-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-ethyl}-4-(4-methoxymethoxy-phenyl)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 205587-47-9
4-(4-Methoxymethoxy-phenyl)-butyric acid

: 205587-46-8
(R)-(-)-1-(3,4-di(t-butyldimethylsiloxy)phenyl)-2-aminoethanol

: 205587-48-0
N-{(R)-2-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-ethyl}-4-(4-methoxymethoxy-phenyl)-butyramide

Guidance literature:: With triethylamine; diethyl dicarbonate; In N,N-dimethyl-formamide; from 0 deg to RT;
DOI:10.3987/com-97-s55

Reference yield:

: 40167-10-0
2-[4-(benzyloxy)phenyl]acetaldehyde

: 205587-48-0
N-{(R)-2-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-ethyl}-4-(4-methoxymethoxy-phenyl)-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / tetrahydrofuran

2: 94 percent / H₂ / 10percent Pd-C / ethanol

3: 96 percent / NaH / dimethylformamide

4: 100 percent / LiOH / methanol; H₂O

5: 82 percent / DEPC, Et₃N / dimethylformamide / from 0 deg to RT

With lithium hydroxide; hydrogen; sodium hydride; triethylamine; diethyl dicarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.3987/com-97-s55

Reference yield:

: 501-94-0
p-hydroxyphenethyl alcohol

: 205587-48-0
N-{(R)-2-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-ethyl}-4-(4-methoxymethoxy-phenyl)-butyramide

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / K₂CO₃ / methanol

2: 88 percent / Dess-Martin / CH₂Cl₂

3: 84 percent / tetrahydrofuran

4: 94 percent / H₂ / 10percent Pd-C / ethanol

5: 96 percent / NaH / dimethylformamide

6: 100 percent / LiOH / methanol; H₂O

7: 82 percent / DEPC, Et₃N / dimethylformamide / from 0 deg to RT

With lithium hydroxide; hydrogen; sodium hydride; potassium carbonate; Dess-Martin periodane; triethylamine; diethyl dicarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.3987/com-97-s55