40167-10-0

Basic information

• Product Name: 4-(PhenylMethoxy)-benzeneacetaldehyde
• Synonyms: 4-(PhenylMethoxy)-benzeneacetaldehyde;2-(4-Benzyloxyphenyl)acetaldehyde;4-Benzyloxyphenylacetaldehyde;4-PhenylMethoxyphenylacetaldehyde;BENZENEACETALDEHYDE, 4-(PHENYLMETHOXY)-
• CAS NO: 40167-10-0
• Molecular Formula: C₁₅H₁₄O₂
• Molecular Weight: 226
• Product Categories: Aromatics
• Mol File: 40167-10-0.mol

Chemical Properties

• Boiling Point: 373.1±22.0 °C(Predicted)
• Appearance: /
• Density: 1.107±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: CDCl3, CD3OD
• CAS DataBase Reference: 4-(PhenylMethoxy)-benzeneacetaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(PhenylMethoxy)-benzeneacetaldehyde(40167-10-0)
• EPA Substance Registry System: 4-(PhenylMethoxy)-benzeneacetaldehyde(40167-10-0)

Safety Data

• Hazardous Substances Data: 40167-10-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-(PhenylMethoxy)-benzeneacetaldehyde is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows it to serve as a building block for the creation of a wide range of molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-(PhenylMethoxy)-benzeneacetaldehyde is utilized as a starting material for the development of new drugs. Its versatility in organic synthesis enables the production of diverse drug candidates with potential therapeutic applications.
Used in Flavor and Fragrance Industry:
4-(PhenylMethoxy)-benzeneacetaldehyde is also employed in the flavor and fragrance industry, where it contributes to the creation of unique scents and flavors for various consumer products. Its chemical properties make it suitable for use in the formulation of perfumes, cosmetics, and the food industry.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 4-(PhenylMethoxy)-benzeneacetaldehyde is used as a precursor for the synthesis of various dyes and pigments. Its chemical structure allows for the development of a range of colorants used in textiles, plastics, and other applications requiring vibrant and stable colors.
Overall, 4-(PhenylMethoxy)-benzeneacetaldehyde is a versatile compound with a wide range of applications across different industries, including organic synthesis, pharmaceuticals, flavor and fragrance, and dyes and pigments. Its unique properties and utility in various synthesis processes make it an essential component in the development of new products and technologies.

Upstream product

• 501-94-0 p-hydroxyphenethyl alcohol 
• 100-39-0 benzyl bromide 
• 68641-16-7 (4-benzyloxy-phenyl)-acetic acid methyl ester 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 82099-81-8 1-(benzyloxy)-4-(2-methoxyethenyl)benzene 
• 36438-64-9 p-benzyloxystyrene 
• 100-44-7 benzyl chloride 
• 61439-59-6 2-(4-benzyloxyphenyl)ethanol 

Downstream Products

• 121537-69-7 4,4-ethylenedioxy-1-(4'-phenylmethoxyphenyl)cyclohexene 
• 205587-50-4 (E)-4-(4-benzyloxyphenyl)-2-butenoic acid ethyl ester 
• 177959-36-3 (2S,3S)-4-(4'-benzyloxyphenyl)-1,2-epoxy-3-hydroxybutane 
• 422321-77-5 (2S,3S)-4-(4'-benzyloxyphenyl)-2,3-O-isopropylidenedioxybutan-1-ol 
• 177959-34-1 (2S,3S)-4-(4'-benzyloxyphenyl)-2,3-O-isopropylidenedioxy-1-p-toluenesulfonyloxybutane 
• 422321-73-1 trans-4-(4-(benzyloxy)phenyl)-2-buten-1-ol 
• 422321-74-2 4-(4'-benzyloxyphenyl)-1-bromobut-2-ene 
• 422321-75-3 ethyl (2R,3S)-4-(4'-benzyloxyphenyl)-2,3-dihydroxybutanoate 
• 422321-76-4 ethyl (2R,3S)-4-(4'-benzyloxyphenyl)-2,3-O-isopropylidenedioxybutanoate 
• 1262680-53-4 N-allyl-1-(4-(benzyloxy)phenyl)-4-(4-methoxyphenyl)-N-methylbut-3-yn-2-amine 
• 1262680-73-8 N-allyl-1-(4-(benzyloxy)phenyl)-4-(p-tolyl)-N-methylbut-3-yn-2-amine 
• 1430737-07-7 1-benzyl-3-(4-benzyloxyphenyl)-7-(tosyl)-1H,7H-pyrrolo[3,2-f]indole-4,8-dione 
• 1430737-09-9 1-benzyl-3-(4-benzyloxyphenyl)-1H,7H-pyrrolo[3,2-f]indole-4,8-dione 
• 1208068-42-1 3-(4-hydroxyphenyl)-1H,7H-pyrrolo[3,2-f]indole-4,8-dione 

Relevant articles and documents

NOVEL LYSOPHOSPHATIDIC ACID DERIVATIVE

PROBLEM TO BE SOLVED: To provide a compound that specifically activates an LPA4 receptor, and a pharmaceutical composition containing the same. SOLUTION: This invention relates to a novel lysophosphatidic acid derivative that has an agonistic action on an LPA4 receptor and is useful for the prevention and/or treatment of a disease with angiodysplasia caused by the LPA4 receptor, or a disease associated with angiopathy, or symptoms associated therewith. This invention also relates to a pharmaceutical composition containing the lysophosphatidic acid derivative. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Butenolide derivative as well as preparation method and application thereof

The invention discloses a butenolide compound as well as a preparation method and an application thereof. The butenolide derivative has the inhibitory activity of protein tyrosine phosphatase 1B (PTP1B), improves insulin resistance of HepG2 cells, generates a remarkable hypoglycemic effect and can be used for preparing a medicine for treating diabetes mellitus.

Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents

Mycobacterium tuberculosis, the causative agent of tuberculosis, relies on thymidylate kinase (MtbTMPK) for the synthesis of thymidine triphosphates and thus also DNA synthesis. Therefore, this enzyme constitutes a potential Achilles heel of the pathogen. Based on a previously reported MtbTMPK 6-aryl-substituted pyridone inhibitor and guided by two co-crystal structures of MtbTMPK with pyridone- and thymine-based inhibitors, we report the synthesis of a series of aryl-shifted cyanopyridone analogues. These compounds generally lacked significant MtbTMPK inhibitory potency, but some analogues did exhibit promising antitubercular activity. Analogue 11i demonstrated a 10-fold increased antitubercular activity (MIC H37Rv, 1.2 μM) compared to literature compound 5. Many analogues with whole-cell antimycobacterial activity were devoid of significant cytotoxicity.

α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease

Increased Gram-negative bacteria resistance to antibiotics is becoming a global problem, and new classes of antibiotics with novel mechanisms of action are required. The caseinolytic protease subunit P (ClpP) is a serine protease conserved among bacteria that is considered as an interesting drug target. ClpP function is involved in protein turnover and homeostasis, stress response, and virulence among other processes. The focus of this study was to identify new inhibitors of Escherichia coli ClpP and to understand their mode of action. A focused library of serine protease inhibitors based on diaryl phosphonate warheads was tested for ClpP inhibition, and a chemical exploration around the hit compounds was conducted. Altogether, 14 new potent inhibitors of E. coli ClpP were identified. Compounds 85 and 92 emerged as most interesting compounds from this study due to their potency and, respectively, to its moderate but consistent antibacterial properties as well as the favorable cytotoxicity profile.

Stereoselective Synthesis of Vinylboronates by Rh-Catalyzed Borylation of Stereoisomeric Mixtures

The stereoselective preparation of vinylboronates via rhodium-catalyzed borylation of E/Z mixtures of vinyl actetates is described, and this method was also extended to synthesis of vinyldiboronates. These transformations feature high functional group compatibility and mild reaction conditions. Control experiments support a mechanism that involved a Rh-catalyzed borylation-isomerization sequence. The isomerization of (Z)-vinylboronates to (E)-isomers was also demonstrated.

Access to β-Ketonitriles through Nickel-Catalyzed Carbonylative Coupling of α-Bromonitriles with Alkylzinc Reagents

Herein, we report a nickel-catalyzed carbonylative coupling of α-bromonitriles and alkylzinc reagents with near stoichiometric carbon monoxide to give β-ketonitriles in good yields. The reaction is catalyzed by a readily available and stable nickel(II) pincer complex. The developed protocol tolerates substrates bearing a variety of functional groups, which would be problematic or incompatible with previous synthetic methods. Additionally, we demonstrate the suitability of the method for carbon isotope labeling by the synthesis of 13C-labeled β-ketonitriles and their transformation into isotopically labeled heterocycles.

ALANINE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE

The description relates to inhibitors of Apoptosis Proteins (TAPs) binding compounds, including Afunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the IAP E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

Design and synthesis of neolamellarin a derivatives targeting heat shock protein 90

In this study, we designed and synthesized a novel family of neolamellarin A derivatives that showed high inhibitory activity toward heat shock protein 90 (Hsp90), a kinase associated with cell proliferation. The 3,4-bis(catechol)pyrrole scaffold and the benzyl group with methoxy modification at N position of pyrrole are essential to the Hsp90 inhibitory activity and cytotoxicity of these compounds. Western blot analysis demonstrated that these compounds induced dramatic depletion of the examined client proteins of Hsp90, and accelerated cancer cell apoptosis. Docking simulations suggested that the binding mode of 9p was similar to that of the VER49009, a potent inhibitor of Hsp90. Further molecular dynamics simulation indicated that the hydrophobic interactions as well as the hydrogen bonds contributed to the high affinity of 9p to Hsp90.

One-carbon homologation of pyrrole carboxaldehyde via wittig reaction and mild hydrolysis of vinyl ether - Toward the synthesis of a sterically locked phytochrome chromophore

Mild hydrolysis of vinyl ether derived from a pyrrole carboxaldehyde corresponding to the B,C-ring component of phytochromobilin chromophore was achieved by treatment with oxalyl chloride in chloroform in the presence of water and ethanol to afford a one-carbon homologated aldehyde. This aldehyde was applied to the synthesis of the sterically locked 15E-anti CD-ring component of the chromophore. Furthermore, the aldehyde could be converted to the intermediate for the sterically locked 5Z-anti AB-ring component.

THIOARYL DERIVATIVES AS GPR120 AGONISTS

The present invention relates to thioaryl derivatives of Formula 1 as defined in the specification, a method for preparing the same, a pharmaceutical composition comprising the same and use thereof. The thioaryl derivatives of Formula 1 according to the present invention promote GLP-1 formation in the gastrointestinal tract and improve insulin resistance in macrophages, pancreas cells, etc. due to anti-inflammatory action, and can accordingly be effectively used for preventing or treating diabetes, complications of diabetes, inflammation, obesity, non-alcoholic fatty liver, steatohepatitis or osteoporosis.