Ibrolipim

Base Information

Chemical Name:Ibrolipim
CAS No.:133208-93-2
Molecular Formula:C19H20BrN2O4P
Molecular Weight:451.257
Hs Code.:
European Community (EC) Number:634-329-1
UNII:07H1561618
DSSTox Substance ID:DTXSID20157989
Nikkaji Number:J692.960E
Wikipedia:Ibrolipim
Wikidata:Q5984863
NCI Thesaurus Code:C75256
ChEMBL ID:CHEMBL34234
Mol file:133208-93-2.mol

Synonyms:4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide;Ibrolipim;NO 1886;NO-1886

Suppliers and Price of Ibrolipim

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
NO-1886
5mg
$ 120.00

Sigma-Aldrich
NO-1886 ≥98% (HPLC)
5mg
$ 172.00

Sigma-Aldrich
NO-1886 ≥98% (HPLC)
25mg
$ 683.00

DC Chemicals
Ibrolipim
003
$ 1900.00

CSNpharm
Ibrolipim
50mg
$ 240.00

Cayman Chemical
NO-1886 ≥98%
25mg
$ 281.00

Cayman Chemical
NO-1886 ≥98%
10mg
$ 125.00

Cayman Chemical
NO-1886 ≥98%
5mg
$ 69.00

Ambeed
Diethyl4-((4-bromo-2-cyanophenyl)carbamoyl)benzylphosphonate 97%
250mg
$ 381.00

Ambeed
Diethyl4-((4-bromo-2-cyanophenyl)carbamoyl)benzylphosphonate 97%
10mg
$ 63.00

Total 7 raw suppliers

Chemical Property of Ibrolipim

Chemical Property:

Vapor Pressure:1.29E-10mmHg at 25°C
Melting Point:160.5-162.1?°C
Boiling Point:512.5°C at 760 mmHg
Flash Point:263.7°C
PSA：98.23000
Density:1.44g/cm³
LogP:5.41218
Storage Temp.:2-8°C
Solubility.:DMSO: ≥20mg/mL
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:450.03441
Heavy Atom Count:27
Complexity:576

Purity/Quality:

98%min ^*data from raw suppliers

NO-1886 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi,T
Statements: 36/37/38-25
Safety Statements: 26-36-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOP(=O)(CC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)Br)C#N)OCC
Uses Antiatherogenic; antiobesity; antidyslipidemia; anticachexia; and antidiabetes/syndrome. Lipoprotein Lipase Activator is an inducer of lipoprotein lipase mRNA.

Technology Process of Ibrolipim

There total 4 articles about Ibrolipim which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1122-58-3
dmap

: 39263-32-6
2-amino-5-bromobenzonitrile

: 118578-91-9
4-[(diethoxyphosphoryl)-methyl]benzoyl chloride

: 133208-93-2
ibrolipim

Guidance literature:: With triethylamine; In dichloromethane; water;

Reference yield:

: 28149-48-6
4-[(diethoxyphosphinyl)methyl]benzoic acid

: 133208-93-2
ibrolipim

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / CH₂Cl₂; dimethylformamide

2: pyridine

With pyridine; thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9506938