tert-butyl N-[[4-[5-[3-amino-6-[2-(1-cyano-1-methylethyl)pyridin-4-yl]pyrazin-2-yl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methylcarbamate

Base Information

Chemical Name:tert-butyl N-[[4-[5-[3-amino-6-[2-(1-cyano-1-methylethyl)pyridin-4-yl]pyrazin-2-yl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methylcarbamate
CAS No.:1402390-56-0
Molecular Formula:C₂₈H₃₀N₈O₃
Molecular Weight:526.598
Hs Code.:

Synonyms:tert-butyl N-[[4-[5-[3-amino-6-[2-(1-cyano-1-methylethyl)pyridin-4-yl]pyrazin-2-yl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methylcarbamate

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Chemical Property of tert-butyl N-[[4-[5-[3-amino-6-[2-(1-cyano-1-methylethyl)pyridin-4-yl]pyrazin-2-yl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methylcarbamate

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Technology Process of tert-butyl N-[[4-[5-[3-amino-6-[2-(1-cyano-1-methylethyl)pyridin-4-yl]pyrazin-2-yl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methylcarbamate

There total 6 articles about tert-butyl N-[[4-[5-[3-amino-6-[2-(1-cyano-1-methylethyl)pyridin-4-yl]pyrazin-2-yl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402390-59-3
2-methyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]propanenitrile

: 1232424-10-0
tert-butyl N-[[4-[5-(3-amino-6-bromopyrazin-2-yl)-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methylcarbamate

: 1402390-56-0
tert-butyl N-[[4-[5-[3-amino-6-[2-(1-cyano-1-methylethyl)pyridin-4-yl]pyrazin-2-yl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methylcarbamate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 150 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 6966-01-4
methyl 3-amino-6-bromopyrazine-2-carboxylate

: 1402390-56-0
tert-butyl N-[[4-[5-[3-amino-6-[2-(1-cyano-1-methylethyl)pyridin-4-yl]pyrazin-2-yl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / 1.5 h / 70 °C

2: triethylamine / N,N-dimethyl-formamide / 18.5 h / 20 °C

3: dibromotriphenylphosphorane; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.75 h / Cooling with ice; Inert atmosphere

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With sodium carbonate; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; dibromotriphenylphosphorane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 153034-86-7
2-chloro-4-iodopyridine

: 1402390-56-0
tert-butyl N-[[4-[5-[3-amino-6-[2-(1-cyano-1-methylethyl)pyridin-4-yl]pyrazin-2-yl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hexamethyldisilazane / toluene; tetrahydrofuran / 0 - 20 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With potassium acetate; sodium hexamethyldisilazane; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water; toluene;