Methyl 3-amino-6-bromopyrazine-2-carboxylate

Base Information

• Chemical Name: Methyl 3-amino-6-bromopyrazine-2-carboxylate
• CAS No.: 6966-01-4
• Molecular Formula: C6H6BrN3O2
• Molecular Weight: 232.037
• Hs Code.: 2933990090
• Mol file: 6966-01-4.mol

Synonyms:Pyrazinecarboxylicacid, 3-amino-6-bromo-, methyl ester (9CI);3-Amino-6-bromo-2-pyrazinecarboxylic acid methyl ester;

Chemical Property of Methyl 3-amino-6-bromopyrazine-2-carboxylate

Chemical Property:

• Appearance/Colour: Orange solid
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 164-166?C
• Refractive Index: 1.615
• Boiling Point: 322.422 °C at 760 mmHg
• PKA: -1.74±0.10(Predicted)
• Flash Point: 148.796 °C
• PSA: 78.10000
• Density: 1.755 g/cm³
• LogP: 1.18910
• Storage Temp.: Refrigerator, Under Inert Atmosphere

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-5-bromopyrazine-3-carboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Pyrazine derivatives as Axl and C-Met receptor enzyme inhibitors.

Technology Process of Methyl 3-amino-6-bromopyrazine-2-carboxylate

There total 3 articles about Methyl 3-amino-6-bromopyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Methyl 3-amino-2-pyrazinecarboxylate (16298-03-6) → methyl 3-amino-6-bromopyrazine-2-carboxylate (6966-01-4)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; for 2h; Heating / reflux;

Reference yield: 80.1%

methanol (67-56-1) + 3-amino-6-bromo-pyrazine-2-carboxylic acid (486424-37-7) → methyl 3-amino-6-bromopyrazine-2-carboxylate (6966-01-4)

Guidance literature:

With sulfuric acid; at 0 - 40 ℃; for 48h;

Reference yield:

3-aminopyrazinoic acid (5424-01-1) → methyl 3-amino-6-bromopyrazine-2-carboxylate (6966-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid

2: bromine; acetic acid

With sulfuric acid; bromine; acetic acid;

DOI:10.1016/j.bmcl.2012.01.077 DOI:10.1016/j.bmcl.2012.02.087

upstream raw materials:

Methyl 3-amino-2-pyrazinecarboxylate

3-aminopyrazinoic acid

methanol

3-amino-6-bromo-pyrazine-2-carboxylic acid

Downstream raw materials:

3-amino-6-bromo-pyrazine-2-carboxylic acid

3-Amino-6-(4-methoxy-phenyl)-pyrazine-2-carboxylic acid methyl ester

3-Amino-5-benzoyl-6-bromo-pyrazine-2-carboxylic acid methyl ester

3-Amino-5-ethoxycarbonylmethyl-6-phenyl-pyrazine-2-carboxylic acid methyl ester

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