2-((4-methoxyphenyl)thio)benzonitrile

Base Information

• Chemical Name: 2-((4-methoxyphenyl)thio)benzonitrile
• CAS No.: 128958-95-2
• Molecular Formula: C₁₄H₁₁NOS
• Molecular Weight: 241.313
• Mol file: 128958-95-2.mol

Synonyms:2-((4-methoxyphenyl)thio)benzonitrile

Chemical Property of 2-((4-methoxyphenyl)thio)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-((4-methoxyphenyl)thio)benzonitrile

There total 12 articles about 2-((4-methoxyphenyl)thio)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4,4'-dimethoxyphenyl disulfide (5335-87-5) + 2-fluorobenzonitrile (394-47-8) → 2-((4-methoxyphenyl)thio)benzonitrile (128958-95-2)

Guidance literature:

With hydridotetakis(triphenylphosphine)rhodium(I); o-phenylenebis(diphenylphosphine); triphenylphosphine; In chlorobenzene; for 6h; Reflux;

DOI:10.1021/ja8049996

Reference yield: 97.7%

1-[(4-methoxyphenyl)sulfanyl]pyrrolidine-2,5-dione (80172-73-2) + o-cyanobromobenzene (2042-37-7) → 2-((4-methoxyphenyl)thio)benzonitrile (128958-95-2)

Guidance literature:

With N,N,N'N'-tetramethyl-1,3-propanediamine; trimethoxonium tetrafluoroborate; copper(II) trifluoroacetate; 1,2-bis-(diphenylphosphino)ethane; In acetonitrile; at 80 ℃; for 3h; Reagent/catalyst;

Reference yield: 87.0%

4-Methoxybenzenethiol (696-63-9) + 3-aminoindazole (874-05-5) → 2-((4-methoxyphenyl)thio)benzonitrile (128958-95-2)

Guidance literature:

With tert.-butylhydroperoxide; copper diacetate; In water; acetonitrile; at 40 ℃; for 18h; Sealed tube;

DOI:10.1039/c9cc05099j

upstream raw materials:

Nitroethane

2-(4-methoxyphenylthio)benzaldehyde

2-fluorobenzonitrile

sodium 4-methoxyphenylthiolate

Refernces

• 1、 -. "Ortho-position imine ester or cyano substituted aryl thioether derivative, and preparation method and application thereof". Paragraph 0131-0135. . Retrieved 2020/06/17.
• 2、 Dong, Zhi-Bing,Balkenhohl, Moritz,Tan, Eric,Knochel, Paul. "Synthesis of Functionalized Diaryl Sulfides by Cobalt-Catalyzed Coupling between Arylzinc Pivalates and Diaryl Disulfides". supporting information. p. 7581 - 7584. Retrieved 2018/11/27.