(R)-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2,3 dihydrobenzo[d][1,3]oxaphosphole-3-oxide

Base Information

Chemical Name:(R)-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2,3 dihydrobenzo[d][1,3]oxaphosphole-3-oxide
CAS No.:1373432-34-8
Molecular Formula:C₁₉H₂₃O₄P
Molecular Weight:346.363
Hs Code.:

Synonyms:(R)-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2,3 dihydrobenzo[d][1,3]oxaphosphole-3-oxide

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Chemical Property of (R)-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2,3 dihydrobenzo[d][1,3]oxaphosphole-3-oxide

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Technology Process of (R)-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2,3 dihydrobenzo[d][1,3]oxaphosphole-3-oxide

There total 2 articles about (R)-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2,3 dihydrobenzo[d][1,3]oxaphosphole-3-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1202032-99-2
(R)-3-(tert-butyl)-3-oxido-2H-benzo[d][1,3]oxaphosphol-4-yl trifluoromethanesulfonate

: 23112-96-1
(2,6-dimethoxyphenyl)boronic acid

: 1373432-34-8
(R)-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2,3 dihydrobenzo[d][1,3]oxaphosphole-3-oxide

Guidance literature:: With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole; In 1,4-dioxane; Inert atmosphere;
DOI:10.1021/acs.joc.5b02649

Reference yield: 87.0%

: 1202032-99-2
(R)-3-(tert-butyl)-3-oxido-2H-benzo[d][1,3]oxaphosphol-4-yl trifluoromethanesulfonate

: 151-10-0
1,3-Dimethoxybenzene

: 1373432-34-8
(R)-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2,3 dihydrobenzo[d][1,3]oxaphosphole-3-oxide

Guidance literature:: 1,3-Dimethoxybenzene; With n-butyllithium; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere; Sealed tube; Cooling with ice;

With zinc dibromide; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere; Sealed tube; Cooling with ice;

(R)-3-(tert-butyl)-3-oxido-2H-benzo[d][1,3]oxaphosphol-4-yl trifluoromethanesulfonate; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (S)-3-tert-butyl-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole; In tetrahydrofuran; at 70 ℃; for 1.16667h; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.joc.5b02649

Reference yield: 95.0%

: 1373432-34-8
(R)-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2,3 dihydrobenzo[d][1,3]oxaphosphole-3-oxide

: 1246888-90-3,1338454-03-7,1373432-09-7
(S)-3-tert-butyl-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole

Guidance literature:: With titanium(IV) isopropylate; In tetrahydrofuran; at 70 ℃; for 16h; stereospecific reaction; Inert atmosphere;
DOI:10.1039/c3cc46009f