(2S,3R)-2-benzyl-3-tert-butyl-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole oxide

Base Information

Chemical Name:(2S,3R)-2-benzyl-3-tert-butyl-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole oxide
CAS No.:1373432-38-2
Molecular Formula:C₂₆H₂₉O₄P
Molecular Weight:436.488
Hs Code.:

Synonyms:(2S,3R)-2-benzyl-3-tert-butyl-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole oxide

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Chemical Property of (2S,3R)-2-benzyl-3-tert-butyl-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole oxide

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Technology Process of (2S,3R)-2-benzyl-3-tert-butyl-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole oxide

There total 3 articles about (2S,3R)-2-benzyl-3-tert-butyl-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1373432-34-8
(R)-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2,3 dihydrobenzo[d][1,3]oxaphosphole-3-oxide

: 100-39-0
benzyl bromide

: 1373432-38-2
(2S,3R)-2-benzyl-3-tert-butyl-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole oxide

Guidance literature:: (R)-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2,3 dihydrobenzo[d][1,3]oxaphosphole-3-oxide; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 1h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at -70 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol300659d

Reference yield:

: 23112-96-1
(2,6-dimethoxyphenyl)boronic acid

: 1373432-38-2
(2S,3R)-2-benzyl-3-tert-butyl-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole oxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -70 °C / Inert atmosphere

2.2: 3 h / -70 - 20 °C / Inert atmosphere

With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; 1.1: Suzuki coupling;
DOI:10.1021/ol300659d

Reference yield:

: 1202032-99-2
(R)-3-(tert-butyl)-3-oxido-2H-benzo[d][1,3]oxaphosphol-4-yl trifluoromethanesulfonate

: 1373432-38-2
(2S,3R)-2-benzyl-3-tert-butyl-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole oxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -70 °C / Inert atmosphere

2.2: 3 h / -70 - 20 °C / Inert atmosphere

With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; 1.1: Suzuki coupling;
DOI:10.1021/ol300659d