3-chloro-5-hydroxybenzamide

Base Information

• Chemical Name: 3-chloro-5-hydroxybenzamide
• CAS No.: 917388-33-1
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.583
• Mol file: 917388-33-1.mol

Synonyms:3-chloro-5-hydroxybenzamide

Chemical Property of 3-chloro-5-hydroxybenzamide

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-chloro-5-hydroxybenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-chloro-5-hydroxybenzamide (cas# 917388-33-1) is an intermediate in the preparation of aminoacetamide acyl guanidines as β-secretase (BACE) inhibitors useful in the treatment of neurological disorders.

Technology Process of 3-chloro-5-hydroxybenzamide

There total 1 articles about 3-chloro-5-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C7H4Cl2O2 → 3-chloro-5-hydroxybenzamide (917388-33-1)

Guidance literature:

C₇H₄Cl₂O₂; With ammonia; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 20 ℃;

With ammonia; In 1,4-dioxane; methanol; at 90 ℃; for 2h; Sealed tube;

Reference yield:

3-chloro-5-hydroxybenzamide (917388-33-1) → 3-(aminomethyl)-5-chlorophenol (862541-23-9)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; Heating / reflux;

Downstream raw materials:

3-(aminomethyl)-5-chlorophenol

Refernces