[4-(5H,11H-Pyrrolo-[2,1-c][1,4]benzodiazepine-10-carbonyl)-3-chloro-phenyl]-2-phenyl-cyclopent-1-enecarboxylic acid amide

Base Information

Chemical Name:[4-(5H,11H-Pyrrolo-[2,1-c][1,4]benzodiazepine-10-carbonyl)-3-chloro-phenyl]-2-phenyl-cyclopent-1-enecarboxylic acid amide
CAS No.:207670-48-2
Molecular Formula:C₃₁H₂₆ClN₃O₂
Molecular Weight:508.019
Hs Code.:

Synonyms:[4-(5H,11H-Pyrrolo-[2,1-c][1,4]benzodiazepine-10-carbonyl)-3-chloro-phenyl]-2-phenyl-cyclopent-1-enecarboxylic acid amide

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Chemical Property of [4-(5H,11H-Pyrrolo-[2,1-c][1,4]benzodiazepine-10-carbonyl)-3-chloro-phenyl]-2-phenyl-cyclopent-1-enecarboxylic acid amide

Chemical Property:

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Technology Process of [4-(5H,11H-Pyrrolo-[2,1-c][1,4]benzodiazepine-10-carbonyl)-3-chloro-phenyl]-2-phenyl-cyclopent-1-enecarboxylic acid amide

There total 3 articles about [4-(5H,11H-Pyrrolo-[2,1-c][1,4]benzodiazepine-10-carbonyl)-3-chloro-phenyl]-2-phenyl-cyclopent-1-enecarboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 2-Phenyl-cyclopent-1-enecarbonyl chloride

: 7285-11-2
chloroform methanol

: ethyl acetate n-hexane

: 22162-53-4
10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine

: 168079-19-4
10,11-Dihydro-10-(2-chloro-4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

: 207670-48-2
[4-(5H,11H-Pyrrolo-[2,1-c][1,4]benzodiazepine-10-carbonyl)-3-chloro-phenyl]-2-phenyl-cyclopent-1-enecarboxylic acid amide

Guidance literature:: With dmap; triethylamine; In dichloromethane;

Reference yield:

: 2-Phenyl-cyclopent-1-enecarbonyl chloride

: 168079-19-4
10,11-Dihydro-10-(2-chloro-4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

: 207670-48-2
[4-(5H,11H-Pyrrolo-[2,1-c][1,4]benzodiazepine-10-carbonyl)-3-chloro-phenyl]-2-phenyl-cyclopent-1-enecarboxylic acid amide

Guidance literature:: With dmap; triethylamine; In dichloromethane;

Reference yield:

: 156774-70-8
2-phenylcyclopent-1-enecarboxylic acid methyl ester

: 207670-48-2
[4-(5H,11H-Pyrrolo-[2,1-c][1,4]benzodiazepine-10-carbonyl)-3-chloro-phenyl]-2-phenyl-cyclopent-1-enecarboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2: triethylamine / dmap / dichloromethane / 16 h / 20 °C

With oxalyl dichloride; triethylamine; dmap; N,N-dimethyl-formamide; In dichloromethane;