1-(3-methylbenzoyl)-5-phenylamino-1H-indazole-3-carboxylic acid ethyl ester

Base Information

Chemical Name:1-(3-methylbenzoyl)-5-phenylamino-1H-indazole-3-carboxylic acid ethyl ester
CAS No.:1448314-49-5
Molecular Formula:C₂₄H₂₁N₃O₃
Molecular Weight:399.449
Hs Code.:

Synonyms:1-(3-methylbenzoyl)-5-phenylamino-1H-indazole-3-carboxylic acid ethyl ester

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Chemical Property of 1-(3-methylbenzoyl)-5-phenylamino-1H-indazole-3-carboxylic acid ethyl ester

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Technology Process of 1-(3-methylbenzoyl)-5-phenylamino-1H-indazole-3-carboxylic acid ethyl ester

There total 5 articles about 1-(3-methylbenzoyl)-5-phenylamino-1H-indazole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1448314-21-3
5-amino-1-(3-methylbenzoyl)-1H-indazole-3-carboxylic acid ethyl ester

: 98-80-6
phenylboronic acid

: 1448314-49-5
1-(3-methylbenzoyl)-5-phenylamino-1H-indazole-3-carboxylic acid ethyl ester

Guidance literature:: With copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 24h; Molecular sieve;
DOI:10.1021/jm400742j

Reference yield:

: 4498-68-4
ethyl 1H-indazole-3-carboxylate

: 1448314-49-5
1-(3-methylbenzoyl)-5-phenylamino-1H-indazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: nitric acid; sulfuric acid / 0.17 h / 0 °C

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C

3: hydrogen; palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 2311.54 Torr

4: copper diacetate; triethylamine / dichloromethane / 24 h / 20 °C / Molecular sieve

With sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; copper diacetate; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm400742j

Reference yield:

: 4498-67-3
1H-Indazole-3-carboxylic acid

: 1448314-49-5
1-(3-methylbenzoyl)-5-phenylamino-1H-indazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 5 h / Reflux

2: nitric acid; sulfuric acid / 0.17 h / 0 °C

3: triethylamine / dichloromethane / 4 h / 0 - 20 °C

4: hydrogen; palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 2311.54 Torr

5: copper diacetate; triethylamine / dichloromethane / 24 h / 20 °C / Molecular sieve

With sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; copper diacetate; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm400742j