tert-butyl (2S,3R)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]decanoate

Base Information

Chemical Name:tert-butyl (2S,3R)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]decanoate
CAS No.:1401227-95-9
Molecular Formula:C₃₄H₄₂F₂N₂O₄S
Molecular Weight:612.781
Hs Code.:

Synonyms:tert-butyl (2S,3R)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]decanoate

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Chemical Property of tert-butyl (2S,3R)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]decanoate

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Technology Process of tert-butyl (2S,3R)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]decanoate

There total 2 articles about tert-butyl (2S,3R)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]decanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1401227-88-0
4-methyl-N-(1-tosyloctyl)benzenesulfonamide

: N-[bis(4-fluorophenyl)methylene]glycine tert-butyl ester

: 1401227-95-9
tert-butyl (2S,3R)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]decanoate

Guidance literature:: With tetrakis(actonitrile)copper(I) hexafluorophosphate; (Rp)-2-(tert-butylthio)-1-(diphenyl-phosphino)ferrocene; caesium carbonate; In tetrahydrofuran; at -20 ℃; for 24h; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c2cc35160a

Reference yield:

: 124-13-0
Octanal

: 70-55-3
toluene-4-sulfonamide

: 1401227-95-9
tert-butyl (2S,3R)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]decanoate

Guidance literature:: Multi-step reaction with 2 steps

1: formic acid / water / 24 h / 0 - 20 °C

2: (Rp)-2-(tert-butylthio)-1-(diphenyl-phosphino)ferrocene; tetrakis(actonitrile)copper(I) hexafluorophosphate; caesium carbonate / tetrahydrofuran / 24 h / -20 °C / Inert atmosphere

With formic acid; tetrakis(actonitrile)copper(I) hexafluorophosphate; (Rp)-2-(tert-butylthio)-1-(diphenyl-phosphino)ferrocene; caesium carbonate; In tetrahydrofuran; water; 1: |Mannich Aminomethylation / 2: |Mannich Aminomethylation;
DOI:10.1039/c2cc35160a