C₂₂H₁₇F₃N₆

Base Information

Chemical Name:C₂₂H₁₇F₃N₆
CAS No.:1420206-00-3
Molecular Formula:C₂₂H₁₇F₃N₆
Molecular Weight:422.412
Hs Code.:

C<sub>22</sub>H<sub>17</sub>F<sub>3</sub>N<sub>6</sub>

Synonyms:C₂₂H₁₇F₃N₆

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Chemical Property of C₂₂H₁₇F₃N₆

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Technology Process of C₂₂H₁₇F₃N₆

There total 10 articles about C₂₂H₁₇F₃N₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 477871-32-2
6-amino-5-bromopyridine-3-carbonitrile

: 1420205-99-7
C₁₆H₁₄F₃N₃

: 1420206-00-3
C₂₂H₁₇F₃N₆

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 100 ℃; Inert atmosphere;

Reference yield:

: 66417-30-9
2-bromo-1-methyl-4-(trifluoromethyl)benzene

: 1420206-00-3
C₂₂H₁₇F₃N₆

Guidance literature:: Multi-step reaction with 7 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 0.17 h / 150 °C / Microwave irradiation

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.17 h / 150 °C / Microwave irradiation

3.1: palladium 10% on activated carbon; hydrogen / methanol; isopropyl alcohol / 50 °C / Inert atmosphere

4.1: hydrogen bromide; sodium nitrite / water / 0 - 20 °C

4.2: 0 - 20 °C

5.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 1 h / 20 °C

7.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen bromide; hydrogen; potassium acetate; acetic acid; triethylamine; sodium nitrite; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 2.1: |Suzuki Coupling / 5.1: |Sonogashira Cross-Coupling / 7.1: |Sonogashira Cross-Coupling;

Reference yield:

: 1124383-00-1
N-(3-bromo-2-pyridinyl)-N’-carboethoxy-thiourea

: 1420206-00-3
C₂₂H₁₇F₃N₆

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol; ethanol / 6 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.17 h / 150 °C / Microwave irradiation

3.1: palladium 10% on activated carbon; hydrogen / methanol; isopropyl alcohol / 50 °C / Inert atmosphere

4.1: hydrogen bromide; sodium nitrite / water / 0 - 20 °C

4.2: 0 - 20 °C

5.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 1 h / 20 °C

7.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; hydrogen bromide; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium nitrite; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; 2.1: |Suzuki Coupling / 5.1: |Sonogashira Cross-Coupling / 7.1: |Sonogashira Cross-Coupling;