(6,7-dimethoxy-1,1-dimethyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

Base Information

Chemical Name:(6,7-dimethoxy-1,1-dimethyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone
CAS No.:1333162-75-6
Molecular Formula:C₂₀H₂₃NO₃
Molecular Weight:325.408
Hs Code.:

Synonyms:(6,7-dimethoxy-1,1-dimethyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

Suppliers and Price of (6,7-dimethoxy-1,1-dimethyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (6,7-dimethoxy-1,1-dimethyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (6,7-dimethoxy-1,1-dimethyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

There total 3 articles about (6,7-dimethoxy-1,1-dimethyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1333162-68-7
N-(2-(2-hydroxypropan-2-yl)-4,5-dimethoxyphenethyl)benzamide

: 1333162-75-6
(6,7-dimethoxy-1,1-dimethyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.3390/molecules16087019

Reference yield:

: 67616-16-4
N-[2-(3,4-dimethoxyphenyl)ethyl]benzamide

: 1333162-75-6
(6,7-dimethoxy-1,1-dimethyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: polyphosphoric acid / dichloromethane / 2 h / 80 °C

2.1: magnesium / diethyl ether / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid / dichloromethane / 0.5 h / 20 °C

With toluene-4-sulfonic acid; magnesium; In diethyl ether; dichloromethane; 1.1: Friedel Crafts acylation;
DOI:10.3390/molecules16087019

Reference yield:

: 32438-32-7
N-(2-acetyl-4,5-dimethoxyphenethyl)benzamide

: 1333162-75-6
(6,7-dimethoxy-1,1-dimethyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium / diethyl ether / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / dichloromethane / 0.5 h / 20 °C

With toluene-4-sulfonic acid; magnesium; In diethyl ether; dichloromethane;
DOI:10.3390/molecules16087019