32438-32-7Relevant academic research and scientific papers
Synthesis and contractile activity of substituted 1,2,3,4- tetrahydroisoquinolines
Ivanov, Iliyan,Nikolova, Stoyanka,Aladjov, Dimo,Stefanova, Iliyana,Zagorchev, Plamen
experimental part, p. 7019 - 7042 (2011/11/05)
A series of different 1-monosubstituted and 1,1-disubstituted 1,2,3,4-tetrahydroisoquinolines was synthesized in high yields from different ketoamides. We have developed a convenient method for the synthesis of disubstituted derivatives by interaction of
Application of the ortho-Lithiation-Cyclization Strategy to N-Benzyl- and N-Phenethylamine Derivatives
Lete, Esther,Collado, M. Isabel,Sotomayor, Nuria,Vicente, Teresa,Villa, Maria-Jesus
, p. 1751 - 1758 (2007/10/03)
The ortho-lithiation-cyclization of iodinated N,N-diacylphenethylamines provides a convenient method for the preparation of 2-(2-acetoamidoethyl)acetophenones and 2-(2-benzamidoethyl)benzophenones, which could be easily transformed into dihydroisoquinolines.By contrast, the N-ethylamino, N-acetylamino, and N-trimethylsilylamino moieties studied as ortho-directing groups provide poor assistance to the metalation of N-benzyl- and N-phenyethylamines and the corresponding isoindolone or isoquinolone derivatives are obtained in low yields.
Fragmentation of Enamides Derived from 6,7-Dimethoxy-4-methyl-2H-1,3-benzothiazin and 3,4-Dihydro-6,7-dimethoxy-1-methylisoquinoline
Wang, Jian,Smith, Richard W.,Fodor, Lajos,Maclean, David B.
, p. 830 - 836 (2007/10/02)
The elctron impact mass spectra of several enamides have been examined.The enamides were prepared by reaction of aroyl halides with 6,7-dimethoxy-4-methyl-1,3-benzothiazin, and with 3,4-dihydro-6,7-dimethoxy-1-metylisoquinoline.The fragmentation pathways that have been proposed are supported by ion composition determinations and by mass-analysed ion kinetic energy spectrometry experiments carried out on the molecular ions and major fragment ions.The spectra are characterized by a loss of carbon monoxide from the molecular ion of each compound, a process which is accompanied by migration of the aryl group.
