methyl (2R,4R)-1-(3,4-dichlorophenylsulfonyl)-4-hydroxypyrrolidine-2-carboxylate

Base Information

Chemical Name:methyl (2R,4R)-1-(3,4-dichlorophenylsulfonyl)-4-hydroxypyrrolidine-2-carboxylate
CAS No.:1408186-45-7
Molecular Formula:C₁₂H₁₃Cl₂NO₅S
Molecular Weight:354.211
Hs Code.:

Synonyms:methyl (2R,4R)-1-(3,4-dichlorophenylsulfonyl)-4-hydroxypyrrolidine-2-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2R,4R)-1-(3,4-dichlorophenylsulfonyl)-4-hydroxypyrrolidine-2-carboxylate

Chemical Property:

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Technology Process of methyl (2R,4R)-1-(3,4-dichlorophenylsulfonyl)-4-hydroxypyrrolidine-2-carboxylate

There total 1 articles about methyl (2R,4R)-1-(3,4-dichlorophenylsulfonyl)-4-hydroxypyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 98-31-7
3,4-dichlorobenzenesulphonyl chloride

: 114676-47-0,775275-31-5,790644-51-8,754962-86-2
(2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl ester

: 1408186-45-7
methyl (2R,4R)-1-(3,4-dichlorophenylsulfonyl)-4-hydroxypyrrolidine-2-carboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield: 99.0%

: 1408186-45-7
methyl (2R,4R)-1-(3,4-dichlorophenylsulfonyl)-4-hydroxypyrrolidine-2-carboxylate

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 1408186-48-0
methyl (2R,4R)-4-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: With trifluorormethanesulfonic acid; In diethyl ether; at 0 - 20 ℃; for 3h; Molecular sieve; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

: 1408186-45-7
methyl (2R,4R)-1-(3,4-dichlorophenylsulfonyl)-4-hydroxypyrrolidine-2-carboxylate

: 79-11-8
chloroacetic acid

: C₁₄H₁₄Cl₃NO₆S

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 0 - 90 ℃; for 0.333333h; Microwave irradiation;
DOI:10.1016/j.ejmech.2012.08.028