methyl (2R,4R)-4-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:methyl (2R,4R)-4-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate
CAS No.:1408186-48-0
Molecular Formula:C₁₉H₁₉Cl₂NO₅S
Molecular Weight:444.336
Hs Code.:

Synonyms:methyl (2R,4R)-4-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate

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Chemical Property of methyl (2R,4R)-4-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate

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Technology Process of methyl (2R,4R)-4-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate

There total 3 articles about methyl (2R,4R)-4-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1408186-45-7
methyl (2R,4R)-1-(3,4-dichlorophenylsulfonyl)-4-hydroxypyrrolidine-2-carboxylate

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 1408186-48-0
methyl (2R,4R)-4-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: With trifluorormethanesulfonic acid; In diethyl ether; at 0 - 20 ℃; for 3h; Molecular sieve; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

: 114676-47-0,775275-31-5,790644-51-8,754962-86-2
(2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl ester

: 1408186-48-0
methyl (2R,4R)-4-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

2: trifluorormethanesulfonic acid / diethyl ether / 3 h / 0 - 20 °C / Molecular sieve; Inert atmosphere

With dmap; trifluorormethanesulfonic acid; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

: 2584-71-6,30724-02-8
cis-hydroxy-D-proline

: 1408186-48-0
methyl (2R,4R)-4-(benzyloxy)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride

2: triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

3: trifluorormethanesulfonic acid / diethyl ether / 3 h / 0 - 20 °C / Molecular sieve; Inert atmosphere

With dmap; thionyl chloride; trifluorormethanesulfonic acid; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1016/j.ejmech.2012.08.028