(S)-4-Methyl-2-[(R)-3-((S)-4-methyl-2-methylamino-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid (R)-1-benzyloxycarbonyl-2-phenyl-ethyl ester

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Chemical Name:(S)-4-Methyl-2-[(R)-3-((S)-4-methyl-2-methylamino-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid (R)-1-benzyloxycarbonyl-2-phenyl-ethyl ester
CAS No.:188909-09-3
Molecular Formula:C₃₄H₄₆N₂O₇
Molecular Weight:594.748
Hs Code.:

Synonyms:(S)-4-Methyl-2-[(R)-3-((S)-4-methyl-2-methylamino-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid (R)-1-benzyloxycarbonyl-2-phenyl-ethyl ester

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Chemical Property of (S)-4-Methyl-2-[(R)-3-((S)-4-methyl-2-methylamino-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid (R)-1-benzyloxycarbonyl-2-phenyl-ethyl ester

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Technology Process of (S)-4-Methyl-2-[(R)-3-((S)-4-methyl-2-methylamino-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid (R)-1-benzyloxycarbonyl-2-phenyl-ethyl ester

There total 1 articles about (S)-4-Methyl-2-[(R)-3-((S)-4-methyl-2-methylamino-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid (R)-1-benzyloxycarbonyl-2-phenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-{3-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoyloxy]-2-oxo-piperidin-1-yl}-4-methyl-pentanoic acid (R)-1-benzyloxycarbonyl-2-phenyl-ethyl ester

: 188909-09-3
(S)-4-Methyl-2-[(R)-3-((S)-4-methyl-2-methylamino-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid (R)-1-benzyloxycarbonyl-2-phenyl-ethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 1h;
DOI:10.1021/jm020482k

Reference yield:

: 188909-09-3
(S)-4-Methyl-2-[(R)-3-((S)-4-methyl-2-methylamino-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid (R)-1-benzyloxycarbonyl-2-phenyl-ethyl ester

: 188909-15-1
4-methyl-2-[3-(4-methyl-2-{methyl-[2-(4-methyl-2-{methyl-[2-(4-methyl-2-methylamino-pentanoyloxy)-propionyl]-amino}-pentanoyloxy)-3-phenyl-propionyl]-amino}-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid 1-carboxy-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent Spectr_. / DCC; DMAP / CH₂Cl₂ / 3 h / 25 °C

2: 99 percent / CF₃CO₂H / CH₂Cl₂ / 1 h / 25 °C

3: 93 percent Spectr_. / H₂ / Pd/C / ethanol / 3 h / 2327.17 - 2585.74 Torr

With dmap; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm020482k

Reference yield:

: 188909-09-3
(S)-4-Methyl-2-[(R)-3-((S)-4-methyl-2-methylamino-pentanoyloxy)-2-oxo-piperidin-1-yl]-pentanoic acid (R)-1-benzyloxycarbonyl-2-phenyl-ethyl ester

: (2S,5R,8S,11R,14S,17R,20S,23R)-5,17-Dibenzyl-2,8,14,20-tetraisobutyl-7,11,13,19-tetramethyl-4,10,16,22-tetraoxa-1,7,13,19-tetraaza-bicyclo[21.3.1]heptacosan-3,6,9,12,15,18,21,27-octaone

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent Spectr_. / DCC; DMAP / CH₂Cl₂ / 3 h / 25 °C

2: 99 percent / CF₃CO₂H / CH₂Cl₂ / 1 h / 25 °C

3: 93 percent Spectr_. / H₂ / Pd/C / ethanol / 3 h / 2327.17 - 2585.74 Torr

4: 65 percent / DPEA; BOP-Cl / CH₂Cl₂ / 48 h / 25 °C

With dmap; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm020482k