1N-(6-amino-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-1N-methyl-3-phenyl-(E)-2-propenamide

Base Information

Chemical Name:1N-(6-amino-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-1N-methyl-3-phenyl-(E)-2-propenamide
CAS No.:199680-96-1
Molecular Formula:C₁₅H₁₆N₄O₃
Molecular Weight:300.317
Hs Code.:

Synonyms:1N-(6-amino-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-1N-methyl-3-phenyl-(E)-2-propenamide

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Chemical Property of 1N-(6-amino-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-1N-methyl-3-phenyl-(E)-2-propenamide

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Technology Process of 1N-(6-amino-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-1N-methyl-3-phenyl-(E)-2-propenamide

There total 3 articles about 1N-(6-amino-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-1N-methyl-3-phenyl-(E)-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 140-10-3
(E)-3-phenylacrylic acid

: 55441-70-8
6-amino-1-methyl-5-(methylamino)pyrimidine-2,4-dione

: 199680-96-1
1N-(6-amino-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-1N-methyl-3-phenyl-(E)-2-propenamide

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol;
DOI:10.1021/jm970515+

Reference yield:

: 14094-37-2
6-amino-5-bromo-1-methylpyrimidine-2,4(1H,3H)-dione

: 199680-96-1
1N-(6-amino-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-1N-methyl-3-phenyl-(E)-2-propenamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂O / 4 h / 70 °C

2: 69 percent / EDC / methanol / 10 h / 20 °C

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; water;
DOI:10.1021/jm011093d

Reference yield:

: 2434-53-9
6-amino-1-methyluracil

: 199680-96-1
1N-(6-amino-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-1N-methyl-3-phenyl-(E)-2-propenamide

Guidance literature:: Multi-step reaction with 3 steps

1: Br₂; NaHCO₃ / methanol / 0.5 h / 20 °C

2: H₂O / 4 h / 70 °C

3: 69 percent / EDC / methanol / 10 h / 20 °C

With bromine; sodium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; water;
DOI:10.1021/jm011093d