4-[3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butyryl]-2-methyl-N-thietan-3-yl-benzamide

Base Information

• Chemical Name: 4-[3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butyryl]-2-methyl-N-thietan-3-yl-benzamide
• CAS No.: 1427274-76-7
• Molecular Formula: C₂₁H₁₈Cl₂F₃NO₂S₂
• Molecular Weight: 508.413
• Mol file: 1427274-76-7.mol

Synonyms:4-[3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butyryl]-2-methyl-N-thietan-3-yl-benzamide

Chemical Property of 4-[3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butyryl]-2-methyl-N-thietan-3-yl-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-[3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butyryl]-2-methyl-N-thietan-3-yl-benzamide

There total 1 articles about 4-[3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butyryl]-2-methyl-N-thietan-3-yl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(E)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-2-methyl-N-thietan-3-yl-benzamide (1332628-88-2) → 4-[3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butyryl]-2-methyl-N-thietan-3-yl-benzamide (1427274-76-7)

Guidance literature:

With triethylamine; tiolacetic acid; at 20 ℃; for 41h; Inert atmosphere;

Reference yield:

4-[3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butyryl]-2-methyl-N-thietan-3-yl-benzamide (1427274-76-7) → 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazol-3-yl]-2-methyl-N-thietan-3-yl-benzamide (1427273-64-0)

Guidance literature:

With potassium hydroxide; hydroxylamine-O-sulfonic acid; In tetrahydrofuran; water; at 20 ℃; for 0.5h;

upstream raw materials:

4-[(E)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-2-methyl-N-thietan-3-yl-benzamide

Downstream raw materials:

4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazol-3-yl]-2-methyl-N-thietan-3-yl-benzamide