Technology Process of 4-[(E)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-2-methyl-N-thietan-3-yl-benzamide
There total 6 articles about 4-[(E)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-2-methyl-N-thietan-3-yl-benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
triethylamine;
In
1,2-dichloro-ethane;
for 3h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: dimethyl sulfoxide / 12 h / 120 °C
2: water; sulfuric acid; acetic acid / 20 °C / Reflux
3: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C
4: triethylamine / dichloromethane / 0 - 20 °C
5: potassium carbonate / triethylamine / 1,2-dichloro-ethane / 3 h / Reflux
With
oxalyl dichloride; sulfuric acid; water; potassium carbonate; acetic acid; triethylamine;
triethylamine; N,N-dimethyl-formamide;
In
dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: water; sulfuric acid; acetic acid / 20 °C / Reflux
2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C
3: triethylamine / dichloromethane / 0 - 20 °C
4: potassium carbonate / triethylamine / 1,2-dichloro-ethane / 3 h / Reflux
With
oxalyl dichloride; sulfuric acid; water; potassium carbonate; acetic acid; triethylamine;
triethylamine; N,N-dimethyl-formamide;
In
dichloromethane; 1,2-dichloro-ethane;
