sodium 3-<7β-(triethylsiloxy)cholesteryl> 2-chlorophenyl phosphate

Base Information

• Chemical Name: sodium 3-<7β-(triethylsiloxy)cholesteryl> 2-chlorophenyl phosphate
• CAS No.: 128548-92-5
• Molecular Formula: C₃₉H₆₃ClO₅PSi*Na
• Molecular Weight: 729.428
• Mol file: 128548-92-5.mol

Synonyms:sodium 3-<7β-(triethylsiloxy)cholesteryl> 2-chlorophenyl phosphate

Chemical Property of sodium 3-<7β-(triethylsiloxy)cholesteryl> 2-chlorophenyl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of sodium 3-<7β-(triethylsiloxy)cholesteryl> 2-chlorophenyl phosphate

There total 5 articles about sodium 3-<7β-(triethylsiloxy)cholesteryl> 2-chlorophenyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Phosphorochloridic acid 2-chloro-phenyl ester (3S,7R,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-7-triethylsilanyloxy-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester → sodium 3-<7β-(triethylsiloxy)cholesteryl> 2-chlorophenyl phosphate (128548-92-5)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; for 0.166667h; Yield given;

DOI:10.1021/jm00170a034

Reference yield:

triethylsilyl chloride (994-30-9) → sodium 3-<7β-(triethylsiloxy)cholesteryl> 2-chlorophenyl phosphate (128548-92-5)

Guidance literature:

Multi-step reaction with 4 steps

1: diisopropylethylamine / dimethylformamide / 4 h / Ambient temperature

2: 1 N NaOH, tetrabutylammonium bromide / tetrahydrofuran / 72 h / Ambient temperature

3: triethylamine / tetrahydrofuran / 4 h / 0 °C

4: 20percent aq. NaHCO₃ / tetrahydrofuran / 0.17 h

With sodium hydroxide; tetrabutylammomium bromide; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm00170a034

Reference yield:

3β-acetoxy-7β-hydroxycholest-5-ene (17974-77-5) → sodium 3-<7β-(triethylsiloxy)cholesteryl> 2-chlorophenyl phosphate (128548-92-5)

Guidance literature:

Multi-step reaction with 4 steps

1: diisopropylethylamine / dimethylformamide / 4 h / Ambient temperature

2: 1 N NaOH, tetrabutylammonium bromide / tetrahydrofuran / 72 h / Ambient temperature

3: triethylamine / tetrahydrofuran / 4 h / 0 °C

4: 20percent aq. NaHCO₃ / tetrahydrofuran / 0.17 h

With sodium hydroxide; tetrabutylammomium bromide; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm00170a034

upstream raw materials:

triethylsilyl chloride

3β-acetoxy-7β-hydroxycholest-5-ene

7β-<(triethylsilyl)oxy>cholesterol

Downstream raw materials:

C₄₂H₅₉ClFN₂O₉P

2-chlorophenyl 3'-(2'-deoxyuridylyl) 3-<7β-(triethylsiloxy)cholesteryl> phosphotriester

2-chlorophenyl 5'-(2'-deoxyuridylyl) 3-<7β-(triethylsiloxy)cholesteryl> phosphotriester