Tesaglitazar

Base Information

Chemical Name:Tesaglitazar
CAS No.:251565-85-2
Molecular Formula:C20H24O7S
Molecular Weight:408.472
Hs Code.:2918990090
European Community (EC) Number:675-830-5
UNII:6734037O3L
DSSTox Substance ID:DTXSID4048773
Nikkaji Number:J1.856.738E
Wikipedia:Tesaglitazar
Wikidata:Q7705411
NCI Thesaurus Code:C75985
Pharos Ligand ID:F7U3QTZB77TG
Metabolomics Workbench ID:149826
ChEMBL ID:CHEMBL282686
Mol file:251565-85-2.mol

Synonyms:(S)-2-ethoxy-3-(4-((4-(methylsulfonyloxy)phenethyl)oxy)phenyl)propanoic acid;(S)-2-ethoxy-3-(4-(2-(4-methylsulphonyloxyphenyl)ethoxy)phenyl)propanoic acid;2-ethoxy-3-(4-((4-(methylsulfonyloxy)phenethyl)oxy)phenyl)propanoic acid;AZ 242;tesaglitazar

Suppliers and Price of Tesaglitazar

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Tesaglitazar
25mg
$ 345.00

Tocris
Tesaglitazar ≥98%(HPLC)
50
$ 934.00

Tocris
Tesaglitazar ≥98%(HPLC)
10
$ 229.00

TCI Chemical
Tesaglitazar >95.0%(HPLC)
25mg
$ 135.00

TCI Chemical
Tesaglitazar >95.0%(HPLC)
100mg
$ 369.00

Medical Isotopes, Inc.
Tesaglitazar
50 mg
$ 2120.00

Matrix Scientific
(S)-2-Ethoxy-3-(4-(4-((methylsulfonyl)-oxy)phenethoxy)phenyl)propanoic acid 95+%
1g
$ 1647.00

Matrix Scientific
(S)-2-Ethoxy-3-(4-(4-((methylsulfonyl)-oxy)phenethoxy)phenyl)propanoic acid 95+%
250mg
$ 742.00

Crysdot
(S)-2-Ethoxy-3-(4-(4-((methylsulfonyl)oxy)phenethoxy)phenyl)propanoicacid 97%
25mg
$ 490.00

ChemScene
Tesaglitazar ≥98.0%
1mg
$ 105.00

Total 35 raw suppliers

Chemical Property of Tesaglitazar

Chemical Property:

Vapor Pressure:8.44E-16mmHg at 25°C
Refractive Index:1.565
Boiling Point:611.3 °C at 760 mmHg
PKA:3.62±0.10(Predicted)
Flash Point:323.5 °C
PSA：107.51000
Density:1.278 g/cm³
LogP:3.75950
Storage Temp.:2-8°C
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:11
Exact Mass:408.12427427
Heavy Atom Count:28
Complexity:556

Purity/Quality:

97% ^*data from raw suppliers

Tesaglitazar ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(CC1=CC=C(C=C1)OCCC2=CC=C(C=C2)OS(=O)(=O)C)C(=O)O
Isomeric SMILES:CCO[C@@H](CC1=CC=C(C=C1)OCCC2=CC=C(C=C2)OS(=O)(=O)C)C(=O)O
Recent ClinicalTrials:ARMOR (Analyzing Renal Mechanisms of Creatinine Excretion in Patients On tesaglitazaR)
Recent EU Clinical Trials:A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study to Evaluate the Effect of Tesaglitazar 1 mg once daily on the Pharmacokinetics of Metformin Following Addition of Tesaglitazar to Metformin Treatment twice daily in Patients with Type 2 Diabetes
Uses Dual -acting peroxisome proliferator-activated receptor (PPAR) α and γ agonist. Antidiabetic. Dual -acting peroxisome proliferator-activated receptor (PPAR) a and agonist. Antidiabetic

Technology Process of Tesaglitazar

There total 4 articles about Tesaglitazar which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6
1,4-dioxane

: 251565-89-6
(S)-2-ethoxy-N-(2-hydroxy-(R)-1-phenylethyl)-3-[4-(2-{4-methanesulfonyloxyphenyl}-ethoxy)phenyl]propanoic amide

: 142-82-5
n-heptane

: 251565-85-2,251565-88-5
tesaglitazar

Guidance literature:: With sulfuric acid; acetic acid; In water; ethyl acetate;

Reference yield: 72.0%

: 251565-91-0
ethyl (2S)-2-ethoxy-3-[4-(2-{4-[(methylsulfonyl)oxy]phenyl}ethoxy)phenyl]propanoate

: lithium hydroxide monohydrate

: 251565-85-2,251565-88-5
tesaglitazar

Guidance literature:: In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 251565-91-0
ethyl (2S)-2-ethoxy-3-[4-(2-{4-[(methylsulfonyl)oxy]phenyl}ethoxy)phenyl]propanoate

: 251565-85-2,251565-88-5
tesaglitazar

Guidance literature:: ethyl (2S)-2-ethoxy-3-[4-(2-{4-[(methylsulfonyl)oxy]phenyl}ethoxy)phenyl]propanoate; With lithium hydroxide; water; In acetone; at 2 - 25 ℃; for 7.5h;

With sulfuric acid; water; acetic acid; In ethyl acetate; acetone; pH=1 - 3;