4-(2-chlorophneyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylic acid

Base Information

Chemical Name:4-(2-chlorophneyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylic acid
CAS No.:136281-07-7
Molecular Formula:C₁₉H₁₆ClNO₃
Molecular Weight:341.794
Hs Code.:

Synonyms:4-(2-chlorophneyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylic acid

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Chemical Property of 4-(2-chlorophneyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylic acid

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Technology Process of 4-(2-chlorophneyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylic acid

There total 6 articles about 4-(2-chlorophneyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

: 136281-06-6
methyl 4-(2-chlorophenyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylate

: 136281-07-7
4-(2-chlorophneyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylic acid

Guidance literature:: With potassium hydroxide; In ethanol; water; for 0.5h; Heating;
DOI:10.1248/cpb.43.616

Reference yield:

: 2-amino-2'-chloro-3,5-dimethylbenzophenone

: 136281-07-7
4-(2-chlorophneyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / pyridine / 3 h / 80 °C

2: 1.) NaH / 1.) DMF, RT, 20 min, 2.) DMF, RT, 1 h

3: 72 percent / 70percent H₂SO₄ / 6 h / 180 °C

4: 100 percent / Et₃N / ethyl acetate / 1.5 h

5: 59.2 percent / tert-BuOK / tetrahydrofuran / 0.5 h

6: 93.8 percent / KOH / ethanol; H₂O / 0.5 h / Heating

With pyridine; potassium hydroxide; sulfuric acid; potassium tert-butylate; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; water; ethyl acetate;
DOI:10.1248/cpb.43.616

Reference yield:

: 1027312-81-7
2-acetamido-2'-chloro-3,5-dimethylbenzophenone

: 136281-07-7
4-(2-chlorophneyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, RT, 20 min, 2.) DMF, RT, 1 h

2: 72 percent / 70percent H₂SO₄ / 6 h / 180 °C

3: 100 percent / Et₃N / ethyl acetate / 1.5 h

4: 59.2 percent / tert-BuOK / tetrahydrofuran / 0.5 h

5: 93.8 percent / KOH / ethanol; H₂O / 0.5 h / Heating

With potassium hydroxide; sulfuric acid; potassium tert-butylate; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; water; ethyl acetate;
DOI:10.1248/cpb.43.616