methyl 4-(2-chlorophenyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylate

Base Information

Chemical Name:methyl 4-(2-chlorophenyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylate
CAS No.:136281-06-6
Molecular Formula:C₂₀H₁₈ClNO₃
Molecular Weight:355.821
Hs Code.:

Synonyms:methyl 4-(2-chlorophenyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylate

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Chemical Property of methyl 4-(2-chlorophenyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylate

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Technology Process of methyl 4-(2-chlorophenyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylate

There total 5 articles about methyl 4-(2-chlorophenyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.2%

2N-hydrochloric acid: 2N-hydrochloric acid

: 39619-07-3
2-methylmalonyl dichloride

: 136281-04-4
2'-chloro-3,5-dimethyl-2-methylaminobenzophenone

: 103-79-7,136675-26-8
1-phenyl-acetone

: 136281-06-6
methyl 4-(2-chlorophenyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; ethyl acetate;

Reference yield: 59.2%

: 136281-05-5
methyl N-<2-(2-chlorobenzoyl)-4,6-dimethylphenyl>-N-methylmalonylamide

: 136281-06-6
methyl 4-(2-chlorophenyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; for 0.5h;
DOI:10.1248/cpb.43.616

Reference yield:

: 2-amino-2'-chloro-3,5-dimethylbenzophenone

: 136281-06-6
methyl 4-(2-chlorophenyl)-1,2-dihydro-2-oxo-1,6,8-trimethyl-3-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / pyridine / 3 h / 80 °C

2: 1.) NaH / 1.) DMF, RT, 20 min, 2.) DMF, RT, 1 h

3: 72 percent / 70percent H₂SO₄ / 6 h / 180 °C

4: 100 percent / Et₃N / ethyl acetate / 1.5 h

5: 59.2 percent / tert-BuOK / tetrahydrofuran / 0.5 h

With pyridine; sulfuric acid; potassium tert-butylate; sodium hydride; triethylamine; In tetrahydrofuran; ethyl acetate;
DOI:10.1248/cpb.43.616