2-methyl-2-(6-(4-methyl-1-(4-(trifluoromethyl)piperidin-1-yl)pentyl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)propanoic acid

Base Information

Chemical Name:2-methyl-2-(6-(4-methyl-1-(4-(trifluoromethyl)piperidin-1-yl)pentyl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)propanoic acid
CAS No.:1257395-67-7
Molecular Formula:C₂₉H₃₅F₆NO₂
Molecular Weight:543.593
Hs Code.:

Synonyms:2-methyl-2-(6-(4-methyl-1-(4-(trifluoromethyl)piperidin-1-yl)pentyl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)propanoic acid

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Chemical Property of 2-methyl-2-(6-(4-methyl-1-(4-(trifluoromethyl)piperidin-1-yl)pentyl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)propanoic acid

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Technology Process of 2-methyl-2-(6-(4-methyl-1-(4-(trifluoromethyl)piperidin-1-yl)pentyl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)propanoic acid

There total 9 articles about 2-methyl-2-(6-(4-methyl-1-(4-(trifluoromethyl)piperidin-1-yl)pentyl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₇F₆NO₂

: 1257395-67-7
2-methyl-2-(6-(4-methyl-1-(4-(trifluoromethyl)piperidin-1-yl)pentyl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)propanoic acid

Guidance literature:: With methanol; sodium hydroxide; In tetrahydrofuran; at 100 ℃; for 0.166667h;
DOI:10.1016/j.bmcl.2011.10.047

Reference yield:

: 149490-75-5
2-(3-hydroxy-phenyl)-2-methyl-propionic acid methyl ester

: 1257395-67-7
2-methyl-2-(6-(4-methyl-1-(4-(trifluoromethyl)piperidin-1-yl)pentyl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: boron trifluoride diethyl etherate / 0.17 h / 20 °C / Inert atmosphere

1.2: 20 - 120 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 1 h / 20 °C / Cooling with ice

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,2-dimethoxyethane; ethanol; water / 100 °C

4.1: sodium tetrahydroborate / methanol / 0.17 h / 20 °C

5.1: phosphorus tribromide / tetrahydrofuran; dichloromethane / 0.33 h / 20 °C / Inert atmosphere

6.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

7.1: methanol; sodium hydroxide / tetrahydrofuran / 0.17 h / 100 °C

With pyridine; methanol; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trifluoride diethyl etherate; phosphorus tribromide; sodium hydrogencarbonate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 3.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.10.047

Reference yield:

: C₂₄H₂₈BrF₃O₂

: 1257395-67-7
2-methyl-2-(6-(4-methyl-1-(4-(trifluoromethyl)piperidin-1-yl)pentyl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2: methanol; sodium hydroxide / tetrahydrofuran / 0.17 h / 100 °C

With methanol; potassium carbonate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.10.047