149490-75-5Relevant articles and documents
CARBOXYLIC ACID-CONTAINING COMPOUNDS, DERIVATIVES THEREOF, AND RELATED METHODS OF USE
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Page/Page column 112, (2010/12/26)
Compounds that modulate gamma secretase (e.g., alter the cleavage pattern of gamma secretase) are described herein. Also disclosed are pharmaceutical compositions, methods of modulating the activity of gamma secretase, and methods of treating Alzheimer's Disease using the compounds described herein.
Biaryl cannabinoid mimetics-Synthesis and structure-activity relationship
Worm, Karin,Zhou, Q. Jean,Stabley, Gabriel J.,DeHaven, Robert N.,Dolle, Roland E.
, p. 3652 - 3656 (2008/02/05)
Synthesis, in vitro biological evaluation, and structure-activity relationships of a biaryl cannabinoid mimetic 2 are reported. Variations in the substitution pattern yielded a number of agonists with low nanomolar affinity. Replacing the phenol group by
Substituted benzopyran analogs for the treatment of inflammation
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, (2008/06/13)
A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I'wherein X, A1, A2, A3, A4, R, R'', R1 and R2 are as described in the specification.