(3S)-N-benzyloxy-4-hydroxy-3-<<1--L-prolyl>amino>butanamide

Base Information

Chemical Name:(3S)-N-benzyloxy-4-hydroxy-3-<<1--L-prolyl>amino>butanamide
CAS No.:221106-67-8
Molecular Formula:C₃₂H₃₈N₄O₆
Molecular Weight:574.677
Hs Code.:

(3S)-N-benzyloxy-4-hydroxy-3-<<1-<N-(2-naphthoyl)-L-valyl>-L-prolyl>amino>butanamide

Synonyms:(3S)-N-benzyloxy-4-hydroxy-3-<<1--L-prolyl>amino>butanamide

Suppliers and Price of (3S)-N-benzyloxy-4-hydroxy-3-<<1--L-prolyl>amino>butanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (3S)-N-benzyloxy-4-hydroxy-3-<<1--L-prolyl>amino>butanamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (3S)-N-benzyloxy-4-hydroxy-3-<<1--L-prolyl>amino>butanamide

There total 8 articles about (3S)-N-benzyloxy-4-hydroxy-3-<<1--L-prolyl>amino>butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 221106-65-6
(3S)-4-(tert-butyldimethylsiloxy)-3-<<1--L-prolyl>amino>butanamide

: 221106-67-8
(3S)-N-benzyloxy-4-hydroxy-3-<<1--L-prolyl>amino>butanamide

Guidance literature:: With pyridine hydrogenfluoride; In tetrahydrofuran; for 22h; Ambient temperature;
DOI:10.1248/cpb.47.11

Reference yield:

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 221106-67-8
(3S)-N-benzyloxy-4-hydroxy-3-<<1--L-prolyl>amino>butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide monohydrochloride, N-methylmorpholine, 1-hydroxy-1H-benzotriazole / 1.) THF, DMF, 0.25 h, 2.) THF, DMF, RT, 18 h

2: 55 percent / HF*pyridine / tetrahydrofuran / 22 h / Ambient temperature

With 4-methyl-morpholine; benzotriazol-1-ol; pyridine hydrogenfluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran;
DOI:10.1248/cpb.47.11

Reference yield:

: 95500-47-3
1-(L-valyl)-L-proline methyl ester monohydrochloride

: 221106-67-8
(3S)-N-benzyloxy-4-hydroxy-3-<<1--L-prolyl>amino>butanamide

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / triethylamine / tetrahydrofuran / 0.5 h

2: 1 M aq. NaOH / methanol / 20 h / Ambient temperature

3: 1.) 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide monohydrochloride, N-methylmorpholine, 1-hydroxybenzotriazole / 1.) THF, 0.25 h, 2.) THF, RT, 14 h

4: 92 percent / 1 M aq. NaOH / methanol / 20 h / Ambient temperature

5: 1.) 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide monohydrochloride, N-methylmorpholine, 1-hydroxy-1H-benzotriazole / 1.) THF, DMF, 0.25 h, 2.) THF, DMF, RT, 18 h

6: 55 percent / HF*pyridine / tetrahydrofuran / 22 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; pyridine hydrogenfluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1248/cpb.47.11