2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid

Base Information

• Chemical Name: 2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid
• CAS No.: 1268500-53-3
• Molecular Formula: C₂₂H₂₀F₃NO₃S₂
• Molecular Weight: 467.533

Synonyms:2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid

Chemical Property of 2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid

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Technology Process of 2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid

There total 4 articles about 2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

ethyl 2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoate (1268500-84-0) → 2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid (1268500-53-3)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 0 ℃;

DOI:10.1002/ardp.201000189

Reference yield:

4-mercapto-2-methylphenol (32281-01-9) → 2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid (1268500-53-3)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / acetonitrile / 4 h / 20 °C / Inert atmosphere

2: caesium carbonate / acetonitrile / 20 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran / 0 °C

With water; caesium carbonate; lithium hydroxide; In tetrahydrofuran; acetonitrile;

DOI:10.1002/ardp.201000189

Reference yield:

5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole (317318-97-1) → 2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid (1268500-53-3)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / acetonitrile / 4 h / 20 °C / Inert atmosphere

2: caesium carbonate / acetonitrile / 20 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran / 0 °C

With water; caesium carbonate; lithium hydroxide; In tetrahydrofuran; acetonitrile;

DOI:10.1002/ardp.201000189

upstream raw materials:

ethyl 2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoate

4-mercapto-2-methylphenol

5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

4-{{2-[4-(trifluoromethyl)phenyl]-4-methylthiazol-5-yl}methylthio}-2-methylphenol

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