2-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)phenyl)acetaldehyde

Base Information

Chemical Name:2-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)phenyl)acetaldehyde
CAS No.:1344997-57-4
Molecular Formula:C₂₂H₂₁F₃N₂O₂S
Molecular Weight:434.482
Hs Code.:

Synonyms:2-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)phenyl)acetaldehyde

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Chemical Property of 2-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)phenyl)acetaldehyde

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Technology Process of 2-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)phenyl)acetaldehyde

There total 8 articles about 2-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)phenyl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1373522-40-7
3-(2-ethyl-3-(2-methoxyvinyl)phenyl)-5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazole

: 1344997-57-4
2-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)phenyl)acetaldehyde

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 70 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jm2016107

Reference yield:

: 1344997-56-3
3-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazole

: 1344997-57-4
2-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)phenyl)acetaldehyde

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; at 70 ℃; for 5h; Inert atmosphere;

Reference yield:

: 1334607-79-2
4,4,5,5-tetramethyl-2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane

: 1344997-57-4
2-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)phenyl)acetaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 1 h / 80 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

2: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.17 h / 120 °C / Microwave irradiation; Sealed vessel; Inert atmosphere

3: hydrogenchloride; water / tetrahydrofuran / 5 h / 70 °C / Inert atmosphere

With hydrogenchloride; potassium phosphate; water; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1: Suzuki Coupling / 2: Suzuki Coupling;