2-bromo-5-(3-(6-cyclopropylpyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazole

Base Information

Chemical Name:2-bromo-5-(3-(6-cyclopropylpyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazole
CAS No.:1401349-14-1
Molecular Formula:C₂₄H₁₈BrN₅O₃S
Molecular Weight:536.409
Hs Code.:

Synonyms:2-bromo-5-(3-(6-cyclopropylpyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazole

Suppliers and Price of 2-bromo-5-(3-(6-cyclopropylpyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-bromo-5-(3-(6-cyclopropylpyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-bromo-5-(3-(6-cyclopropylpyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazole

There total 9 articles about 2-bromo-5-(3-(6-cyclopropylpyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401349-13-0
5-(3-(6-cyclopropylpyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine

: 1401349-14-1
2-bromo-5-(3-(6-cyclopropylpyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazole

Guidance literature:: With tert.-butylnitrite; copper(ll) bromide; In acetonitrile; at 50 ℃; for 3h;

Reference yield:

: 1670-81-1,142396-03-0
1H-Indole-5-carboxylic acid

: 1401349-14-1
2-bromo-5-(3-(6-cyclopropylpyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 10 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1.25 h / 65 - 80 °C

2: hydrazine / ethanol / 12 h / Reflux

3: ethanol / 2 h / Reflux

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / toluene / 12 h / Reflux

5: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C

6: sodium hydride / N,N-dimethyl-formamide; mineral oil / -25 °C

7: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 1 h / 90 °C / microwave irradiation; Inert atmosphere; Sealed tube

8: potassium phosphate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 120 °C / Inert atmosphere

9: trifluoroacetic acid / 0.17 h / 120 °C / Microwave irradiation

10: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 3 h / 50 °C

With potassium phosphate; tert.-butylnitrite; iodine; potassium acetate; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide; copper(ll) bromide; hydrazine; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 1011-65-0
5-methoxycarbonylindole

: 1401349-14-1
2-bromo-5-(3-(6-cyclopropylpyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 9 steps

1: hydrazine / ethanol / 12 h / Reflux

2: ethanol / 2 h / Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / toluene / 12 h / Reflux

4: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C

5: sodium hydride / N,N-dimethyl-formamide; mineral oil / -25 °C

6: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 1 h / 90 °C / microwave irradiation; Inert atmosphere; Sealed tube

7: potassium phosphate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 120 °C / Inert atmosphere

8: trifluoroacetic acid / 0.17 h / 120 °C / Microwave irradiation

9: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 3 h / 50 °C

With potassium phosphate; tert.-butylnitrite; iodine; potassium acetate; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide; copper(ll) bromide; hydrazine; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;