1-[(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-propan-2-ol

Base Information

Chemical Name:1-[(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-propan-2-ol
CAS No.:361534-93-2
Molecular Formula:C₂₃H₃₈O₅Si
Molecular Weight:422.637
Hs Code.:

Synonyms:1-[(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-propan-2-ol

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Chemical Property of 1-[(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-propan-2-ol

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Technology Process of 1-[(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-propan-2-ol

There total 7 articles about 1-[(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 75-16-1
methylmagnesium bromide

: 361534-89-6
[(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-acetaldehyde

: 361534-93-2
1-[(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-propan-2-ol

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; for 1h;
DOI:10.1021/ol016355k

Reference yield:

: 361534-73-8
(2S,4aS,6R,7S,8aR)-6-Hydroxymethyl-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

: 361534-93-2
1-[(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 2,6-lutidine / CH₂Cl₂ / 1 h / -78 °C

2: CH₂Cl₂ / 3 h / -78 - 0 °C

3: 1.33 g / molecular sieves 4 A / dimethylsulfoxide / 0.67 h / 80 °C

4: 87 percent / DIBAH / CH₂Cl₂; hexane / 1 h / -78 °C

5: 89 percent / tetrahydrofuran / 1 h / 0 - 20 °C

With 2,6-dimethylpyridine; 4 A molecular sieve; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; 5: Grignard reaction;
DOI:10.1021/ol016355k

Reference yield:

: 1053634-48-2
(2S,4R,5S)-4-((2S,3S)-3-Hydroxymethyl-3-methyl-oxiranylmethyl)-2-phenyl-[1,3]dioxan-5-ol

: 361534-93-2
1-[(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / PPTS / CH₂Cl₂ / 20 °C

2: 2,6-lutidine / CH₂Cl₂ / 1 h / -78 °C

3: CH₂Cl₂ / 3 h / -78 - 0 °C

4: 1.33 g / molecular sieves 4 A / dimethylsulfoxide / 0.67 h / 80 °C

5: 87 percent / DIBAH / CH₂Cl₂; hexane / 1 h / -78 °C

6: 89 percent / tetrahydrofuran / 1 h / 0 - 20 °C

With 2,6-dimethylpyridine; 4 A molecular sieve; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; 6: Grignard reaction;
DOI:10.1021/ol016355k